NUDT9

NUDT9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q33, 1QVJ
Identifiers
Aliases	NUDT9, NUDT10, nudix hydrolase 9
External IDs	OMIM: 606022 MGI: 1921417 HomoloGene: 11435 GeneCards: NUDT9
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	87,459,455 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	104,065,379 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• hydrolase activity; • ADP-ribose diphosphatase activity; • ADP-sugar diphosphatase activity; • adenosine-diphosphatase activity;
Cellular component	• mitochondrial matrix; • intracellular; • extracellular exosome; • mitochondrion; • cell junction; • nuclear membrane;
Biological process	• nucleobase-containing small molecule catabolic process; • IDP catabolic process; • ADP catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	53343
	74167
	ENSG00000170502
	ENSMUSG00000029310
	Q9BW91
	Q8BVU5
	NM_001248011; NM_024047; NM_198038
	NM_028794
	NP_001234940; NP_076952; NP_932155
	NP_083070
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000170502 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029310 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.
Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.
"Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

Lin S, Gasmi L, Xie Y, et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta. 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID 11825615.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang HT, Yan ZQ, Hu XB, et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35 (8): 747–51. PMID 12897971.
Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID 12948489.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Carloto A, Costas MJ, Cameselle JC, et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2" (PDF). Biochim. Biophys. Acta. 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170502 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029310 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11385575-5] Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.

[pmid12427752-6] Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.

[entrez-7] "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

NUDT9

References

Further reading