NRON

ncRNA Repressor of NFAT (nuclear factor of activated T cells)
	Predicted secondary structure and sequence conservation of NRON
Identifiers
Symbol	NRON
Rfam	RF00636
Other data
RNA type	Gene
Domain(s)	Eukaryota
SO	0001263
PDB structures	PDBe

NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]

Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.

References

Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–1573. doi:10.1126/science.1115901. PMID 16141075.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (PDF). Nature. 420 (6915): 563–573. doi:10.1038/nature01266. PMID 12466851.
Numata K, Kanai A, Saito R, Kondo S, Adachi J, Wilming LG, Hume DA, Hayashizaki Y, Tomita M (June 2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Research. 13 (6B): 1301–1306. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.

External links

Page for NRON at Rfam

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[pmid16141075-1] Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–1573. doi:10.1126/science.1115901. PMID 16141075.

[pmid12466851-2] Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (PDF). Nature. 420 (6915): 563–573. doi:10.1038/nature01266. PMID 12466851.

[pmid12819127-3] Numata K, Kanai A, Saito R, Kondo S, Adachi J, Wilming LG, Hume DA, Hayashizaki Y, Tomita M (June 2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Research. 13 (6B): 1301–1306. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.