NPTXR

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.[5][6]

NPTXR
Identifiers
AliasesNPTXR, NPR, neuronal pentraxin receptor
External IDsOMIM: 609474 MGI: 1920590 HomoloGene: 8620 GeneCards: NPTXR
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,818,452 bp[1]
End38,844,028 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23467

73340

Ensembl

ENSG00000221890

ENSMUSG00000022421

UniProt

O95502

Q99J85

RefSeq (mRNA)

NM_058178
NM_014293

NM_030689

RefSeq (protein)

NP_055108

n/a

Location (UCSC)Chr 22: 38.82 – 38.84 MbChr 15: 79.79 – 79.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.[6]

See also

  • NPTX2, Neuronal pentraxin II

References

  1. GRCh38: Ensembl release 89: ENSG00000221890 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022421 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176.
  6. "Entrez Gene: NPTXR neuronal pentraxin receptor".

Further reading

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