NF-kappa-B-activating protein

NKAP
Identifiers
Aliases	NKAP, NFKB activating protein, MRXSHD
External IDs	OMIM: 300766 MGI: 1914300 HomoloGene: 134325 GeneCards: NKAP
Gene location (Human)
Chr.	X chromosome (human)[1]
End	119,943,751 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	37,150,746 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• chromatin DNA binding; • GO:0001948 protein binding; • RNA binding; • chromatin binding;
Cellular component	• cell nucleus; • nucleoplasm; • cytosol;
Biological process	• Notch signaling pathway; • stem cell population maintenance; • hematopoietic stem cell proliferation; • haematopoiesis; • granulocyte differentiation; • negative regulation of transcription from RNA polymerase II promoter; • T cell differentiation in thymus; • positive regulation of alpha-beta T cell differentiation; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of protein targeting to mitochondrion; • negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	79576
	67050
	ENSG00000101882
	ENSMUSG00000016409
	Q8N5F7
	Q9D0F4
	NM_024528
	NM_025937
	NP_078804
	NP_080213
	Wikidata
View/Edit Human	View/Edit Mouse

NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000101882 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000016409 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB (Oct 2003). "Identification of a nuclear protein that promotes NF-kappaB activation". Biochem Biophys Res Commun. 310 (3): 720–4. doi:10.1016/j.bbrc.2003.09.074. PMID 14550261.
"Entrez Gene: NKAP NF-kappaB activating protein".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ghiorzo P, Mantelli M, Gargiulo S, et al. (2004). "Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression". Hum. Pathol. 35 (8): 1029–37. doi:10.1016/j.humpath.2004.02.017. PMID 15297971.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Zhande R, Karsan A (2007). "Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2467–74. doi:10.1152/ajpheart.00649.2006. PMID 17237249.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101882 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016409 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14550261-5] Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB (Oct 2003). "Identification of a nuclear protein that promotes NF-kappaB activation". Biochem Biophys Res Commun. 310 (3): 720–4. doi:10.1016/j.bbrc.2003.09.074. PMID 14550261.

[entrez-6] "Entrez Gene: NKAP NF-kappaB activating protein".

NF-kappa-B-activating protein

References

Further reading