Mga, max dimerization protein

MGA
Identifiers
Aliases	MGA, MAD5, MXD5, MAX dimerization protein, MAX dimerization protein MGA
External IDs	OMIM: 616061 MGI: 1352483 HomoloGene: 49351 GeneCards: MGA
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	41,773,081 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	119,969,581 bp[2]
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948 protein binding; • protein dimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus; • nucleoplasm; • MLL1 complex;
Biological process	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • negative regulation of G0 to G1 transition; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	23269
	29808
	ENSG00000174197
	ENSMUSG00000033943
	Q8IWI9
	A2AWL7
	NM_001080541; NM_001164273
	NM_001164274; NM_013720
	NP_001074010; NP_001157745
	NP_001157746; NP_038748
	Wikidata
View/Edit Human	View/Edit Mouse

MGA, MAX dimerization protein is a protein that in humans is encoded by the MGA gene. [5]

References

GRCh38: Ensembl release 89: ENSG00000174197 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033943 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MGA, MAX dimerization protein". Retrieved 2018-03-23.

Parsons KS, Hsu AC, Wark PA (January 2014). "TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection". Clin. Exp. Allergy. 44 (1): 91–101. doi:10.1111/cea.12218. PMID 24131248.
Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M (March 2014). "MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1". Cancer Discov. 4 (3): 292–303. doi:10.1158/2159-8290.CD-13-0799. PMID 24362264.
Duan C, Yang X, Zhang X, Feng J, Liu Z, Que H, Johnson H, Zhao Y, Fan Y, Lu Y, Zhang H, Huang Y, Xiu B, Feng X (August 2015). "Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry". Sci Rep. 5: 13073. doi:10.1038/srep13073. PMC 4536492. PMID 26272389.

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