MIR34A
MicroRNA 34a (miR-34a) is a MicroRNA that in humans is encoded by the MIR34A gene.[3]
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| Aliases | MIR34A, MIRN34A, miRNA34A, mir-34, mir-34a, microRNA 34a | ||||||||||||||||||||||||
| External IDs | OMIM: 611172 GeneCards: MIR34A | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 1: 9.15 – 9.15 Mb | n/a | |||||||||||||||||||||||
| PubMed search | [2] | n/a | |||||||||||||||||||||||
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Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
Clinical relevance
miR-34a suppresses the gene expression of the NAMPT gene which encodes the nicotinamide phosphoribosyltransferase (Nampt) enzyme which is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway, resulting in reduced NAD.[4] miR-34a suppression of gene expression also reduces levels of sirtuin 1.[4] Aging and obesity increases levels of miR-34a.[4]
References
- GRCh38: Ensembl release 89: ENSG00000284357 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA 34a".
- Yaku K, Okabe K, Nakagawa T (2018). "NAD Metabolism: Implications in Aging and Longevity". Ageing Research Reviews. 47: 1–17. doi:10.1016/j.arr.2018.05.006. PMID 29883761.
Further reading
- Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, Lam KK, Lee KF, Yeung WS (June 2010). "MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells". Carcinogenesis. 31 (6): 1037–44. doi:10.1093/carcin/bgq066. PMID 20351093.
- Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257.
- Zauli G, Voltan R, di Iasio MG, Bosco R, Melloni E, Sana ME, Secchiero P (May 2011). "miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells". Clinical Cancer Research. 17 (9): 2712–24. doi:10.1158/1078-0432.CCR-10-3244. PMID 21367750.
- Forte E, Salinas RE, Chang C, Zhou T, Linnstaedt SD, Gottwein E, Jacobs C, Jima D, Li QJ, Dave SS, Luftig MA (June 2012). "The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells". Journal of Virology. 86 (12): 6889–98. doi:10.1128/JVI.07056-11. PMC 3393554. PMID 22496226.
- Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J (September 2009). "miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53". Blood. 114 (10): 2181–92. doi:10.1182/blood-2009-02-205062. PMID 19584398.
- Welch C, Chen Y, Stallings RL (July 2007). "MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells". Oncogene. 26 (34): 5017–22. doi:10.1038/sj.onc.1210293. PMID 17297439.
- Siemens H, Jackstadt R, Hünten S, Kaller M, Menssen A, Götz U, Hermeking H (December 2011). "miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions". Cell Cycle. 10 (24): 4256–71. doi:10.4161/cc.10.24.18552. PMID 22134354.
- Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G, Dahiya R (2012). "MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells". PLoS One. 7 (1): e29722. doi:10.1371/journal.pone.0029722. PMC 3250472. PMID 22235332.
- {{cite journal | vauthors = Lou WJ, Chen Q, Liu L, Qian C | title = [miR-34s--a tumor suppression protein p53 highly related microRNA] | journal = Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji | volume = 32 | issue = 5 | pages = 423–30 | date = May 2010 | pmid = 20466628 | doi = 10.3724/SP.J.1005.2010.00423
This article incorporates text from the United States National Library of Medicine, which is in the public domain.