MIER1

Mesoderm induction early response protein 1 is a protein that in humans is encoded by the MIER1 gene.[5][6][7]

MIER1
Identifiers
AliasesMIER1, ER1, MI-ER1, MIER1 transcriptional regulator
External IDsOMIM: 616848 MGI: 1918398 HomoloGene: 136176 GeneCards: MIER1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.3Start66,924,895 bp[1]
End66,988,619 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57708

71148

Ensembl

ENSG00000198160

ENSMUSG00000028522

UniProt

Q8N108

Q5UAK0

RefSeq (mRNA)

NM_001039081
NM_001286221
NM_001286222
NM_001286223
NM_027696

RefSeq (protein)

NP_001034170
NP_001273150
NP_001273151
NP_001273152
NP_081972

Location (UCSC)Chr 1: 66.92 – 66.99 MbChr 4: 103.11 – 103.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

MIER1 has been shown to interact with HDAC1.[6]

References
  1. GRCh38: Ensembl release 89: ENSG00000198160 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028522 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL (Jul 2002). "Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization". Gene. 295 (1): 79–88. doi:10.1016/S0378-1119(02)00823-5. PMID 12242014.
  6. Ding Z, Gillespie LL, Paterno GD (Jan 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–8. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.
  7. "Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis)".

Further reading
  • Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, Gillespie LL (Nov 1998). "Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines". Gene. 222 (1): 77–82. doi:10.1016/S0378-1119(98)00473-9. PMID 9813250.
  • Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  • Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  • Ding Z, Gillespie LL, Mercer FC, Paterno GD (Jul 2004). "The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter". The Journal of Biological Chemistry. 279 (27): 28009–16. doi:10.1074/jbc.M403793200. PMID 15117948.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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