MEX3D

MEX3D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DGR
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	OMIM: 611009 MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	1,568,058 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	80,387,659 bp[2]
Gene ontology
Molecular function	• AU-rich element binding; • metal ion binding; • nucleic acid binding; • RNA binding; • mRNA 3'-UTR AU-rich region binding;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • cell nucleus;
Biological process	• mRNA destabilization; • mRNA localization resulting in posttranscriptional regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	399664
	237400
	ENSG00000181588
	ENSMUSG00000048696
	Q86XN8
	Q3UE17
	NM_001174118; NM_203304
	NM_198615
	NP_001167589; NP_976049
	NP_941017
	Wikidata
View/Edit Human	View/Edit Mouse

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[5][6]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[6]

References

GRCh38: Ensembl release 89: ENSG00000181588 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048696 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: mex-3 homolog D (C. elegans)".
Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181588 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048696 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: mex-3 homolog D (C. elegans)".

[pmid14769789-6] Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

MEX3D

Function

Structure

References

Further reading