Matrilin-2

Matrilin-2 is a matrilin protein that in humans is encoded by the MATN2 gene.[5][6][7]

MATN2
Identifiers
AliasesMATN2, matrilin 2
External IDsOMIM: 602108 MGI: 109613 HomoloGene: 20538 GeneCards: MATN2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q22.1-q22.2Start97,868,840 bp[1]
End98,036,724 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4147

17181

Ensembl

ENSG00000132561

ENSMUSG00000022324

UniProt

O00339

Q3TQ80

RefSeq (mRNA)

NM_002380
NM_030583
NM_001317748

NM_016762
NM_001358780

RefSeq (protein)

NP_001304677
NP_002371
NP_085072

NP_058042
NP_001345709

Location (UCSC)Chr 8: 97.87 – 98.04 MbChr 15: 34.31 – 34.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000132561 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022324 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Deak F, Piecha D, Bachrati C, Paulsson M, Kiss I (May 1997). "Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily". J Biol Chem. 272 (14): 9268–74. doi:10.1074/jbc.272.14.9268. PMID 9083061.
  6. Mates L, Korpos E, Deak F, Liu Z, Beier DR, Aszodi A, Kiss I (Mar 2002). "Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices". Matrix Biol. 21 (2): 163–74. doi:10.1016/S0945-053X(01)00194-9. PMID 11852232.
  7. "Entrez Gene: MATN2 matrilin 2".

Further reading


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