Mòjiāng virus

Mòjiāng virus
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Class:	Monjiviricetes
Order:	Mononegavirales
Family:	Paramyxoviridae
Genus:	Henipavirus
Species:	Mojiang henipavirus
Synonyms
	Mòjiāng Paramyxovirus; Mòjiāng Henipa-like virus;

Mòjiāng virus (MojV), officially Mojiang henipavirus, is a virus in the family Paramyxoviridae. Based on phylogenetic studies, Mòjiāng virus is placed in the genus Henipavirus or described as a henipa-like virus[1]. Antibodies raised against Mòjiāng virus glycoproteins are serologically distinct from other Henipaviruses (among which higher cross-reactivity is observed)[2][3]. It was first identified in 2012 when a cluster of patients were diagnosed with severe pneumonia connected to an abandoned mine in Mojiang Hani Autonomous County, Yunnan Province in China. Samples from mammal species present in the cave including Rhinolophus ferrumequinum, Rattus flavipectus, and Crocidura dracula were tested for viruses and sequenced. There were 38 sequence reads obtained closely related to members of the Henipavirus genus. Infectious virus particles could only be recovered from 4 samples of R. flavipectus and were cultured in Vero E6, BHK-21, and HEp-2 cells. While no person-to-person transmission was documented, the full range of mammalian hosts susceptible Mòjiāng virus is unknown.[4]

The cell surface receptor for Mòjiāng virus remains unknown. Unlike all other known Henipavirus members, Mòjiāng virus does not bind Ephrin B2/B3. The Mòjiāng virus attachment glycoprotein (MojV-G) lacks an Ephrin B2 binding site and does not bind other common paramyxovirus receptors, including sialic acid or CD150, in cell culture.[3]

References

"Genus: Henipavirus - Paramyxoviridae - Mononegavirales". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2020-05-07.
Li, Yaohui; Li, Ruihua; Wang, Meirong; Liu, Yujiao; Yin, Ying; Zai, Xiaodong; Song, Xiaohong; Chen, Yi; Xu, Junjie; Chen, Wei (2020). "Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice". Viruses. 12 (4): 480. doi:10.3390/v12040480. PMID 32340278.
Rissanen, Ilona; Ahmed, Asim A.; Azarm, Kristopher; Beaty, Shannon; Hong, Patrick; Nambulli, Sham; Duprex, W. Paul; Lee, Benhur; Bowden, Thomas A. (2017). "Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses". Nature Communications. 8: 16060. Bibcode:2017NatCo...816060R. doi:10.1038/ncomms16060. ISSN 2041-1723. PMC 5510225. PMID 28699636.
Wu, Zhiqiang; Yang, Li; Yang, Fan; Ren, Xianwen; Jiang, Jinyong; Dong, Jie; Sun, Lilian; Zhu, Yafang; Zhou, Hongning; Jin, Qi (2014). "Novel Henipa-like Virus, Mojiang Paramyxovirus, in Rats, China, 2012". Emerging Infectious Diseases. 20 (6): 1064–1066. doi:10.3201/eid2006.131022. ISSN 1080-6040. PMC 4036791. PMID 24865545.

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[1] "Genus: Henipavirus - Paramyxoviridae - Mononegavirales". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2020-05-07.

[2] Li, Yaohui; Li, Ruihua; Wang, Meirong; Liu, Yujiao; Yin, Ying; Zai, Xiaodong; Song, Xiaohong; Chen, Yi; Xu, Junjie; Chen, Wei (2020). "Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice". Viruses. 12 (4): 480. doi:10.3390/v12040480. PMID 32340278.

[:0-3] Rissanen, Ilona; Ahmed, Asim A.; Azarm, Kristopher; Beaty, Shannon; Hong, Patrick; Nambulli, Sham; Duprex, W. Paul; Lee, Benhur; Bowden, Thomas A. (2017). "Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses". Nature Communications. 8: 16060. Bibcode:2017NatCo...816060R. doi:10.1038/ncomms16060. ISSN 2041-1723. PMC 5510225. PMID 28699636.

[4] Wu, Zhiqiang; Yang, Li; Yang, Fan; Ren, Xianwen; Jiang, Jinyong; Dong, Jie; Sun, Lilian; Zhu, Yafang; Zhou, Hongning; Jin, Qi (2014). "Novel Henipa-like Virus, Mojiang Paramyxovirus, in Rats, China, 2012". Emerging Infectious Diseases. 20 (6): 1064–1066. doi:10.3201/eid2006.131022. ISSN 1080-6040. PMC 4036791. PMID 24865545.