Lim homeobox 9

LHX9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DMQ
Identifiers
Aliases	LHX9, LIM homeobox 9
External IDs	OMIM: 606066 MGI: 1316721 HomoloGene: 7816 GeneCards: LHX9
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	197,935,478 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	138,848,577 bp[2]
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • GO:0001948 protein binding; • GO:0001106 transcription corepressor activity; • metal ion binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II regulatory region sequence-specific DNA binding;
Cellular component	• cell nucleus;
Biological process	• cellular proliferation; • male gonad development; • negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • female gonad development; • gonad morphogenesis; • dorsal spinal cord interneuron anterior axon guidance; • regulation of transcription from RNA polymerase II promoter; • neuron differentiation; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	56956
	16876
	ENSG00000143355
	ENSMUSG00000019230
	Q9NQ69
	Q9WUH2
	NM_001014434; NM_020204; NM_001370213
	NM_001025565; NM_001042577; NM_010714
	NP_001014434; NP_064589; NP_001357142
	NP_001020736; NP_001036042; NP_034844
	Wikidata
View/Edit Human	View/Edit Mouse

LIM homeobox 9 is a protein that in humans is encoded by the LHX9 gene.[5]

Function

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000143355 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019230 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: LIM homeobox 9".

Lim homeobox 9

Function

References

Further reading