Left-right determination factor 1
Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. [5]
Function
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
References
- GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.
Further reading
- Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
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