LSP1

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.[5][6]

LSP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1
External IDsOMIM: 153432 MGI: 96832 HomoloGene: 1750 GeneCards: LSP1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start1,852,970 bp[1]
End1,892,267 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4046

16985

Ensembl

ENSG00000130592
ENSG00000288199

ENSMUSG00000018819

UniProt

P33241

P19973

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 11: 1.85 – 1.89 MbChr 7: 142.46 – 142.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

References
  1. ENSG00000288199 GRCh38: Ensembl release 89: ENSG00000130592, ENSG00000288199 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018819 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784.
  6. "Entrez Gene: LSP1 lymphocyte-specific protein 1".

Further reading
  • Jongstra-Bilen J, Young AJ, Chong R, Jongstra J (1990). "Human and mouse LSP1 genes code for highly conserved phosphoproteins". J. Immunol. 144 (3): 1104–10. PMID 2295815.
  • Klein DP, Jongstra-Bilen J, Ogryzlo K, et al. (1989). "Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane". Mol. Cell. Biol. 9 (7): 3043–8. PMC 362773. PMID 2674678.
  • Li Y, Guerrero A, Howard TH (1995). "The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines". J. Immunol. 155 (7): 3563–9. PMID 7561054.
  • Misener VL, Hui C, Malapitan IA, et al. (1995). "Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells". J. Cell Sci. 107 (12): 3591–600. PMID 7706408.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Howard T, Li Y, Torres M, et al. (1994). "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein". Blood. 83 (1): 231–41. PMID 8274738.
  • May W, Korenberg JR, Chen XN, et al. (1993). "Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family". Genomics. 15 (3): 515–20. doi:10.1006/geno.1993.1102. PMID 8468046.
  • Thompson AA, Omori SA, Gilly MJ, et al. (1997). "Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms". Genomics. 32 (3): 352–7. doi:10.1006/geno.1996.0129. PMID 8838798.
  • Huang CK, Zhan L, Ai Y, Jongstra J (1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils". J. Biol. Chem. 272 (1): 17–9. doi:10.1074/jbc.272.1.17. PMID 8995217.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Palker TJ, Fong AM, Scearce RM, et al. (1999). "Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation". Hybridoma. 17 (6): 497–507. doi:10.1089/hyb.1998.17.497. PMID 9890705.
  • Pulford K, Jones M, Banham AH, et al. (1999). "Lymphocyte-specific protein 1: a specific marker of human leucocytes". Immunology. 96 (2): 262–71. doi:10.1046/j.1365-2567.1999.00677.x. PMC 2326732. PMID 10233704.
  • Zhang Q, Li Y, Howard TH (2000). "Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains". J. Immunol. 165 (4): 2052–8. doi:10.4049/jimmunol.165.4.2052. PMID 10925289.
  • Zhang Q, Li Y, Howard TH (2002). "Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains". Cell Motil. Cytoskeleton. 49 (4): 179–88. doi:10.1002/cm.1031. PMID 11746662.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wong MJ, Malapitan IA, Sikorski BA, Jongstra J (2003). "A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids". Biochim. Biophys. Acta. 1642 (1–2): 17–24. doi:10.1016/S0167-4889(03)00082-X. PMID 12972289.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs.00955. PMID 15090600.
  • Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
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