LSM6

LSM6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	LSM6, YDR378C, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607286 MGI: 1925901 HomoloGene: 38271 GeneCards: LSM6
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	146,200,000 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	78,821,140 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • RNA binding;
Cellular component	• cytoplasm; • cytosol; • intracellular ribonucleoprotein complex; • nucleoplasm; • small nuclear ribonucleoprotein complex; • spliceosomal complex; • extracellular exosome; • cell nucleus; • P-body; • U6 snRNP; • nucleolus; • small nucleolar ribonucleoprotein complex; • U4/U6 x U5 tri-snRNP complex; • U2-type precatalytic spliceosome; • Lsm2-8 complex;
Biological process	• tRNA processing; • mRNA processing; • RNA splicing; • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; • rRNA processing; • mRNA splicing, via spliceosome; • maturation of SSU-rRNA;
	Sources:Amigo / QuickGO
Orthologs
	11157
	78651
	ENSG00000164167
	ENSMUSG00000031683
	P62312
	P62313
	NM_007080
	NM_001191004; NM_030145
	NP_009011
	NP_001177933; NP_084421
	Wikidata
View/Edit Human	View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.[5][6][7]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.

The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

References

GRCh38: Ensembl release 89: ENSG00000164167 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031683 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
"Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (inactive 2020-01-22). PMC 1370355. PMID 12515382.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164167 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031683 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10369684-5] Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.

[pmid10523320-6] Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.

[entrez-7] "Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

LSM6

References

Further reading