LHX2

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	OMIM: 603759 MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	124,033,301 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	38,369,733 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• metal ion binding; • sequence-specific DNA binding; • chromatin binding; • transcription factor activity, RNA polymerase II transcription factor binding; • DNA binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • RNA polymerase II regulatory region sequence-specific DNA binding;
Cellular component	• cell nucleus; • intracellular;
Biological process	• negative regulation of transcription regulatory region DNA binding; • mesoderm development; • telencephalon development; • neural tube closure; • retina development in camera-type eye; • cerebral cortex development; • transcription, DNA-templated; • axon guidance; • axon extension; • hair follicle development; • maintenance of epithelial cell apical/basal polarity; • neurogenesis; • brain development; • olfactory bulb development; • nervous system development; • dorsal/ventral pattern formation; • positive regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • neuron differentiation; • anatomical structure formation involved in morphogenesis; • telencephalon regionalization; • transcription from RNA polymerase II promoter; • negative regulation of gene expression, epigenetic; • negative regulation of neurogenesis; • positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9355
	16870
	ENSG00000106689
	ENSMUSG00000000247
	P50458
	Q9Z0S2
	NM_004789
	NM_001290646; NM_010710
	NP_004780
	NP_001277575; NP_034840
	Wikidata
View/Edit Human	View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]

Interactions

LHX2 has been shown to interact with CITED2.[8]

References

GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
"Entrez Gene: LHX2 LIM homeobox 2".
Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. PMID 10593900.
Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. doi:10.1038/11970. PMID 10431247.
Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–157. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649822-5] Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.

[pmid10051612-6] Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.

[entrez-7] "Entrez Gene: LHX2 LIM homeobox 2".

[pmid10593900-8] Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

LHX2

Interactions

References

Further reading