Kua-UEV

TMEM189-UBE2V1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2A4D, 2C2V, 2HLW
Identifiers
Aliases	TMEM189-UBE2V1, CROC-1B, CROC1B, KUA-UEV, Kua-UEV, TMEM189-UBE2V1 readthrough
External IDs	HomoloGene: 100008 GeneCards: TMEM189-UBE2V1
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	50,153,637 bp[1]
Gene ontology
Molecular function	• ubiquitin protein ligase binding; • GO:1904264, GO:1904822 ubiquitin protein ligase activity; • GO:0001948 protein binding; • ubiquitin conjugating enzyme activity;
Cellular component	• cytoplasm; • integral component of membrane; • endoplasmic reticulum membrane; • membrane; • endoplasmic reticulum; • cytosol; • ubiquitin conjugating enzyme complex; • UBC13-UEV1A complex; • protein complex; • ubiquitin ligase complex; • extracellular exosome; • cell nucleus; • nucleoplasm; • macromolecular complex;
Biological process	• protein ubiquitination; • protein polyubiquitination; • Fc-epsilon receptor signaling pathway; • protein K63-linked ubiquitination; • nucleotide-binding oligomerization domain containing signaling pathway; • positive regulation of transcription, DNA-templated; • stimulatory C-type lectin receptor signaling pathway; • regulation of DNA repair; • regulation of transcription, DNA-templated; • T cell receptor signaling pathway; • cell differentiation; • postreplication repair; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • activation of MAPK activity; • JNK cascade; • positive regulation of NF-kappaB transcription factor activity; • interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	387522
	n/a
	ENSG00000124208
	n/a
	Q13404
	n/a
	NM_003349; NM_199203
	n/a
NP_001155977; NP_954580; NP_954673; NP_001027459; NP_001244322;
	NP_001244323; NP_001244324; NP_001244325; NP_001244326; NP_001244327; NP_001244328; NP_001269504; NP_001269505; NP_001269506; NP_001269507; NP_001269508; NP_001269509; NP_068823; NP_071887; NP_954595; NP_954673
	n/a
	Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.[3]

The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.[3]

References

GRCh38: Ensembl release 89: ENSG00000124208 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1".

Long M (2001). "A new function evolved from gene fusion". Genome Res. 10 (11): 1655–7. doi:10.1101/gr.165700. PMID 11076848.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Rothofsky ML, Lin SL (1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter". Gene. 195 (2): 141–9. doi:10.1016/S0378-1119(97)00097-8. PMID 9305758.
Sancho E, Vilá MR, Sánchez-Pulido L, et al. (1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol. Cell. Biol. 18 (1): 576–89. doi:10.1128/mcb.18.1.576. PMC 121525. PMID 9418904.
Xiao W, Lin SL, Broomfield S, et al. (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family". Nucleic Acids Res. 26 (17): 3908–14. doi:10.1093/nar/26.17.3908. PMC 147796. PMID 9705497.
Ma L, Broomfield S, Lavery C, et al. (1998). "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines". Oncogene. 17 (10): 1321–6. doi:10.1038/sj.onc.1202058. PMID 9771976.
Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair". Cell. 96 (5): 645–53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880.
Deng L, Wang C, Spencer E, et al. (2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell. 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. PMID 11057907.
Thomson TM, Lozano JJ, Loukili N, et al. (2001). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Res. 10 (11): 1743–56. doi:10.1101/gr.GR-1405R. PMC 310942. PMID 11076860.
Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124208 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1".

Kua-UEV

References

Further reading