Katalin Kariko

Katalin Karikó (born 17 January 1955 in Szolnok, Hungary) is a Hungarian biochemist who specializes in RNA-mediated mechanisms. Her research has been the development of vitro-transcribed mRNA for protein therapies. She currently serves as the Senior Vice President at BioNTech RNA Pharmaceuticals.

Karikó's work includes scientific research of RNA-mediated immune activation resulting in the co-discovery of the nucleoside modifications that suppress the immunogenicity of RNA. This is seen as expanding the therapeutic potential of mRNA. She holds patents granted in the United States for application of non-immunogenic, nucleoside-modified RNA. She co-founded and served as CEO of RNARx from 2006-2013.[1]. Katalin Karikó is the mother of 2-time Olympic Gold Medalist Susan Francia.

Katalin Karikó

Select publications
  • Anderson B, Muramatsu H, Nallagatla SR, Bevilacqua P, Sansing L, Weissman D, Karikó K: Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res 38: 5884-92, 2010.
  • Karikó, K., Muramatsu, H., Welsh, FA., Ludwig, J., Kato, H., Akira, S., Weissman, D.: Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Molecular Therapy 16: 1833-1840, 2008.
  • Karikó K, Buckstein M, Ni H, Weissman D.: Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23(2): 165-75, 2005. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
  • Karikó K, Weissman D, Welsh FA: Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab 24(11): 1288-304, 2004.
  • Karikó K, Ni H, Capodici J, Lamphier M, Weissman D.: mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279(13): 12542-12550, 2004.

References
  1. "Katalin Kariko - Associate Professor of Neurosurgery in Philadelphia, Pennsylvania, United States Of America | eMedEvents". www.emedevents.com. Retrieved 2020-04-27.
  2. Elsevier. "Transforming RNA research into future treatments: Q&A with 2 biotech leaders". Elsevier Connect. Retrieved 2020-04-27.
  3. "Keener 2018 Nat Med mRNA news.pdf". Google Docs. Retrieved 2020-04-27.
  4. , "RNA containing modified nucleosides and methods of use thereof", issued 2006-08-21
  5. , "RNA containing modified nucleosides and methods of use thereof", issued 2013-03-15
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