Karmella Haynes

Karmella Ann Haynes is a biomedical engineer and Associate Professor at Emory University. She researches how chromatin is used to control cell development in biological tissue.

Karmella Haynes
Alma materWashington University in St. Louis
Florida A&M University
Harvard Medical School
Davidson College
Scientific career
InstitutionsArizona State University

Early life and education

Haynes is originally from St. Louis.[1] She attended Florida A&M University, graduating in 1999 with a bachelor's degree in biology.[2] She then attended Washington University in St. Louis for her postgraduate studies, working with Sarah Elgin on DNA and gene expression. In 2006 she received her Ph.D in molecular genetics from the University.[2] She spent her summers working at Massachusetts Institute of Technology.[3]

Research and career

Haynes completed postdoctoral fellowships at Davidson College, in 2008, and Harvard Medical School in 2011.[2] While at Davidson College as a Howard Hughes Medical Institute Fellow, Haynes won publication of the year from the Journal of Biological Engineering for her article on modifying E. coli bacteria to perform a computational calculation.[4][5][6][7] At Davidson College, Haynes redesigned the undergraduate bioinformatics teaching course.[8] At Harvard Medical School Haynes worked in the laboratory of Pamela Silver, combining chromatin dynamics and synthetic biology.[3][9]

In 2011 Haynes was appointed to Arizona State University.[10][11] Since joining Arizona State University, Haynes has been the faculty advisor for the International Genetically Engineered Machines Competition.[12] She was awarded a K01 grant in 2015, to study the use of modular peptide motifs to build synthetic chromatin proteins that activate dormant therapeutic genes.[13] She hopes to increase the use of technology in therapeutics, working on tissue regeneration and customisable protein-based drugs.[14] By engineering genes and proteins, the Haynes group create epigenetic machinery that can regulate DNA.[15] The proteins themselves are fusion transcription factors, which can target particular genes.[16]

In 2018, Haynes moved to the W.H. Coulter Biomedical Engineering Department at Georgia Tech/Emory University.

Haynes has appeared on PBS, talking about biotechnology and disease.[17] Alongside research, Haynes is an accomplished artist.[18][19] In 2011 she painted her poster presentation for the annual Synthetic biology conference.[20] Her artwork is still on the walls at Harvard University.[3] She is a member of the Building with Biology public engagement project.[21] She has been featured twice on Science Friday.[22]

References

  1. "About". Karmella Haynes | Artist. 2015-04-05. Retrieved 2018-05-10.
  2. "2017 General Purpose". www.ncbi.nlm.nih.gov. Retrieved 2018-05-10.
  3. "Karmella Haynes: Turning the Dials". The Scientist. Retrieved 2018-05-10.
  4. "Living computers solve complex math puzzle". NBC News. 2008-06-02. Retrieved 2018-05-10.
  5. "Environment". The Telegraph. 2016-03-30. ISSN 0307-1235. Retrieved 2018-05-10.
  6. "Calculating Bacteria: Real Computer Bugs?". NPR.org. Retrieved 2018-05-10.
  7. Haynes, Karmella A.; Broderick, Marian L.; Brown, Adam D.; Butner, Trevor L.; Dickson, James O.; Harden, W. Lance; Heard, Lane H.; Jessen, Eric L.; Malloy, Kelly J. (2008). "Engineering bacteria to solve the Burnt Pancake Problem". Journal of Biological Engineering. 2 (1): 8. doi:10.1186/1754-1611-2-8. ISSN 1754-1611. PMC 2427008. PMID 18492232.
  8. "Time to Teach" (PDF). HHMI. Retrieved 2018-05-10.
  9. Haynes, Karmella A.; Ceroni, Francesca; Flicker, Daniel; Younger, Andrew; Silver, Pamela A. (2012). "A Sensitive Switch for Visualizing Natural Gene Silencing in Single Cells". ACS Synthetic Biology. 1 (3): 99–106. doi:10.1021/sb3000035. PMC 3331714. PMID 22530199.
  10. "Engineers from Day One". Issuu. Retrieved 2018-05-10.
  11. "Karmella Haynes". asu.pure.elsevier.com. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  12. "Team:Arizona State/Team - 2017.igem.org". 2017.igem.org. Retrieved 2018-05-10.
  13. Karmella, Haynes. "Synthetic chromatin for cancer research". Grantome.
  14. "314: Dr. Karmella Haynes: Expressing Her Creativity Making Epigenetic Machinery and Designing Biological Devices - People Behind the Science Podcast". www.peoplebehindthescience.com. 2015-10-12. Retrieved 2018-05-10.
  15. "Karmella Haynes-Farrell | EBRC". www.ebrc.org. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  16. "BME Lecture Series: Karmella Haynes, Arizona State University | The Henry Samueli School of Engineering at UC Irvine". engineering.uci.edu. Retrieved 2018-05-10.
  17. "Career Profile: Synthetic Biologist Karmella Haynes". PBS LearningMedia. Retrieved 2018-05-10.
  18. "Combining art and science: Karmella Haynes interview". betterposters.blogspot.co.uk. 2011-09-22. Retrieved 2018-05-10.
  19. "Karmella Haynes - Artist". The Scientist. Retrieved 2018-05-10.
  20. "More art & science – hand painted poster at Synthetic Biology #synbio5 – by Karmella Haynes". Jonathan Eisen's Lab. 2011-06-16. Retrieved 2018-05-10.
  21. "Meet Our Scientists". www.buildingwithbiology.org. Retrieved 2018-05-10.
  22. "Karmella Haynes - Science Friday". Science Friday. Retrieved 2018-05-10.
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