Kelch-like protein 12

KLHL12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VPJ
Identifiers
Aliases	KLHL12, C3IP1, DKIR, hDKIR, kelch like family member 12
External IDs	OMIM: 614522 MGI: 2385619 HomoloGene: 23317 GeneCards: KLHL12
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	202,928,636 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	134,491,018 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• ubiquitin-protein transferase activity; • GO:0001948 protein binding; • identical protein binding;
Cellular component	• cytosol; • COPII-coated ER to Golgi transport vesicle; • Cul3-RING ubiquitin ligase complex; • intracellular membrane-bounded organelle; • cytoplasmic vesicle; • microtubule organizing center; • Golgi membrane; • COPII vesicle coat;
Biological process	• COPII vesicle coating; • Wnt signaling pathway; • protein monoubiquitination; • negative regulation of canonical Wnt signaling pathway; • vesicle-mediated transport; • protein ubiquitination; • ER to Golgi vesicle-mediated transport; • neural crest formation; • neural crest cell development;
	Sources:Amigo / QuickGO
Orthologs
	59349
	240756
	ENSG00000117153
	ENSMUSG00000026455
	Q53G59
	Q8BZM0
	NM_001303051; NM_001303109; NM_021633
	NM_153128; NM_001311136
	NP_001289980; NP_001290038; NP_067646
	NP_001298065; NP_694768
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene.[5][6]

Interactions

KLHL12 has been shown to interact with RIT1[7] and CUL3.[7]

References

GRCh38: Ensembl release 89: ENSG00000117153 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026455 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
"Entrez Gene: KLHL12 kelch-like 12 (Drosophila)".
Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mai A, Jung SK, Yonehara S (October 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, et al. (September 2005). "Identification of specific autoantigens in Sjögren's syndrome by SEREX". Immunology. 116 (1): 53–63. doi:10.1111/j.1365-2567.2005.02197.x. PMC 1802401. PMID 16108817.
Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT (April 2006). "The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation". Nature Cell Biology. 8 (4): 348–57. doi:10.1038/ncb1381. PMID 16547521.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117153 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026455 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: KLHL12 kelch-like 12 (Drosophila)".

[pmid18303015-7] Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.

Kelch-like protein 12

Interactions

References

Further reading