KLC3

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.[5]

KLC3
Identifiers
AliasesKLC3, KLC2, KLC2L, KLCt, KNS2B, kinesin light chain 3
External IDsOMIM: 601334 MGI: 1277971 HomoloGene: 14899 GeneCards: KLC3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.32Start45,333,434 bp[1]
End45,351,520 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

147700

232943

Ensembl

ENSG00000104892

ENSMUSG00000040714

UniProt

Q6P597

Q91W40

RefSeq (mRNA)

NM_145275
NM_177417

NM_001286038
NM_001286039
NM_146182

RefSeq (protein)

NP_803136

NP_001272967
NP_001272968
NP_666294

Location (UCSC)Chr 19: 45.33 – 45.35 MbChr 7: 19.39 – 19.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.[5]

Interactions

KLC3 has been shown to interact with YWHAH.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000104892 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040714 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KLC3 kinesin light chain 3".
  6. Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

Further reading


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