Jyotsna Dhawan

Jyotsna Dhawan is an Indian Cell and Developmental Biologist, Emeritus Scientist at Centre for Cellular and Molecular Biology [1][2] and Visiting Professor, Institute for Stem Cell Science and Regenerative Medicine (inStem).[1][3] Dhawan's research has focused on adult stem cell function and skeletal muscle regeneration.[1][3][2][4] Dhawan is the current (2019-2021) President of the Indian Society for Cell Biology[2][5] and the Indian Society of Developmental Biologists (2017-2020).[2][6] Dhawan was elected as a fellow to the Indian National Science Academy in 2019.[2][7]

Early Life and education

Dhawan's father Satish Dhawan was a faculty at the Indian Institute of Science and.[8] Dhawan's mother Nalini, was a cytogeneticist.[8] She completed her Masters in Botany from Delhi University in 1983.[9][1] She contemplated quitting her master's degree however, a summer internship in yeast genetics at the Tata Institute of Fundamental Research, convinced her to pursue a PhD.[9] She completed her PhD from Boston University in 1991.[1][3] She completed her postdoctoral training at Stanford University studying muscle stem cells and gene therapy in 1995.[3][1]

Career

Dhawan joined Centre for Cellular and Molecular Biology as faculty in 1996 [3] and started her lab studying the biology of muscle stem cells and muscle repair. From 2009–2014, she helped set up the Institute for Stem Cell Science and Regenerative Medicine (inStem) in Bangalore and served as Senior Professor and Dean.[3][1] In 2014, she returned to Centre for Cellular and Molecular Biology and retained ties to InStem as a visiting professor.[1][10]

Dhawan has been an active advocate for establishing India as a leader in biomedical research.[11] She serves as the Scientist In Charge of Centre for Cellular and Molecular Biology’s iHub, an innovation space with an incubation center for biomedical startups [3] and has served on several scientific review committees, scientific task forces and advisory boards at the national and institutional level.[2] She has also been a part on the editorial board of Physiological Genomics, BBRC and Frontiers in Cell and Developmental Biology [2]

Selected publications
  • MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation Soji Sebastian, Prethish Sreenivas, Ramkumar Sambasivan, Sirisha Cheedipudi, Prashanth Kandalla, Grace K. Pavlath, Jyotsna Dhawan Proceedings of the National Academy of Sciences Mar 2009, 106 (12) 4719–4724; DOI: 10.1073/pnas.0807136106[12]
  • Srikar Krishna, Aparna Nair, Sirisha Cheedipudi, Deepak Poduval, Jyotsna Dhawan, Dasaradhi Palakodeti, Yashoda Ghanekar, Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata, Nucleic Acids Research, Volume 41, Issue 1, 1 January 2013, Pages 599–616[13]
  • Sirisha Cheedipudi, Deepika Puri, Amena Saleh, Hardik P. Gala, Mohammed Rumman, Malini S. Pillai, Prethish Sreenivas, Reety Arora, Jeeva Sellathurai, Henrik Daa Schrøder, Rakesh K. Mishra, Jyotsna Dhawan, A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene, Nucleic Acids Research, Volume 43, Issue 13, 27 July 2015, Pages 6236–6256[14]

References
  1. https://www.ccmb.res.in/People/Research-Group/Jyotsna-Dhawan
  2. "Loop | Jyotsna Dhawan". loop.frontiersin.org.
  3. "People". Muscle stem cell Lab.
  4. "Dr. Jyotsna Dhawan".
  5. "ISCB Home Page". iscb.org.in.
  6. "InSDB :: Indian Society for Developmetal Biologist". www.devbioindia.org.
  7. "INSA :: Indian Fellow Detail". www.insaindia.res.in.
  8. https://connect.iisc.ac.in/2017/08/father-satish-dhawan/
  9. "Flexing muscle (stem cells) with Jyotsna". The Life of Science. February 27, 2017.
  10. "Dr. Jyotsna Dhawan's Talk | Chemical Engineering". www.che.iitb.ac.in.
  11. Dhawan, Jyotsna; Gokhale, Rajesh S.; Verma, Inder M. (December 2, 2005). "Bioscience in India: Times Are Changing". Cell. 123 (5): 743–745. doi:10.1016/j.cell.2005.11.018. PMID 16325565 – via www.cell.com.
  12. Sebastian, Soji; Sreenivas, Prethish; Sambasivan, Ramkumar; Cheedipudi, Sirisha; Kandalla, Prashanth; Pavlath, Grace K.; Dhawan, Jyotsna (2009-03-24). "MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation". Proceedings of the National Academy of Sciences. 106 (12): 4719–4724. doi:10.1073/pnas.0807136106. ISSN 0027-8424. PMID 19264965.
  13. Krishna, Srikar; Nair, Aparna; Cheedipudi, Sirisha; Poduval, Deepak; Dhawan, Jyotsna; Palakodeti, Dasaradhi; Ghanekar, Yashoda (2013-01-01). "Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata". Nucleic Acids Research. 41 (1): 599–616. doi:10.1093/nar/gks1020. ISSN 0305-1048.
  14. Cheedipudi, Sirisha; Puri, Deepika; Saleh, Amena; Gala, Hardik P.; Rumman, Mohammed; Pillai, Malini S.; Sreenivas, Prethish; Arora, Reety; Sellathurai, Jeeva; Schrøder, Henrik Daa; Mishra, Rakesh K. (2015-07-27). "A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene". Nucleic Acids Research. 43 (13): 6236–6256. doi:10.1093/nar/gkv567. ISSN 0305-1048.
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