Intelectin-1

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.[5][6][7] Intelectin-1 functions both as a receptor for bacterial arabinogalactans[5] and for lactoferrin.[8]

ITLN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDsOMIM: 609873 MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start160,876,540 bp[1]
End160,885,180 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55600

16429

Ensembl

ENSG00000179914

ENSMUSG00000038209

UniProt

Q8WWA0

O88310

RefSeq (mRNA)

NM_017625

NM_010584

RefSeq (protein)

NP_060095

NP_034714

Location (UCSC)Chr 1: 160.88 – 160.89 MbChr 1: 171.52 – 171.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.[9][10]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000179914 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038209 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (June 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". The Journal of Biological Chemistry. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366.
  6. Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (January 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID 11181563.
  7. "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".
  8. Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.
  9. Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL (August 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–10. doi:10.1038/nsmb.3053. PMC 4526365. PMID 26148048.
  10. Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT (March 2016). "Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition". The Journal of Biological Chemistry. 291 (11): 5596–610. doi:10.1074/jbc.M115.709212. PMC 4786701. PMID 26755729.

Further reading

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