INO80B (gene)

INO80 complex subunit B is a protein that in humans is encoded by the INO80B gene. [4]

INO80 stabilizes replication forks and counteracts mislocalization of H2A.Z
INO80B
Identifiers
AliasesINO80B, HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, ZNHIT4, hIes2, PAPA1, INO80 complex subunit B
External IDsOMIM: 616456 MGI: 1917270 HomoloGene: 32566 GeneCards: INO80B
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.1Start74,455,087 bp[1]
End74,457,944 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

83444

70020

Ensembl

ENSG00000115274

n/a

UniProt

Q9C086

Q99PT3

RefSeq (mRNA)

NM_031288

NM_023547

RefSeq (protein)

NP_112578

NP_076036

Location (UCSC)Chr 2: 74.46 – 74.46 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.

References
  1. GRCh38: Ensembl release 89: ENSG00000115274 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: INO80 complex subunit B". Retrieved 2016-12-13.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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