IGF2BP2

IGF2BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQH
Identifiers
Aliases	IGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDs	OMIM: 608289 MGI: 1890358 HomoloGene: 4774 GeneCards: IGF2BP2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	185,825,056 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	22,163,299 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• mRNA 5'-UTR binding; • GO:0001948 protein binding; • mRNA binding; • translation regulator activity; • mRNA 3'-UTR binding; • nucleic acid binding; • RNA binding;
Cellular component	• cytoplasm; • cytoskeleton; • cell nucleus; • cytosol;
Biological process	• regulation of cytokine biosynthetic process; • anatomical structure morphogenesis; • negative regulation of translation; • mRNA transport; • regulation of translation; • regulation of mRNA stability; • transport;
	Sources:Amigo / QuickGO
Orthologs
	10644
	319765
	ENSG00000073792
	ENSMUSG00000033581
	Q9Y6M1
	Q5SF07
NM_001007225; NM_001291869; NM_001291872; NM_001291873; NM_001291874;
	NM_001291875; NM_006548
	NM_183029
NP_001007226; NP_001278798; NP_001278801; NP_001278802; NP_001278803;
	NP_001278804; NP_006539
	NP_898850
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.[5][6][7]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

References

GRCh38: Ensembl release 89: ENSG00000073792 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033581 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC 2193003. PMID 10190901.
Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
"Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497.
Brants JR, Ayoubi TA, Chada K, et al. (2004). "Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2". FEBS Lett. 569 (1–3): 277–83. doi:10.1016/j.febslet.2004.05.075. PMID 15225648.
Ping S, Wang S, Zhang J, Peng X (2005). "Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells". Int. J. Biochem. Cell Biol. 37 (3): 616–27. doi:10.1016/j.biocel.2004.08.007. PMID 15618018.
Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203–12. doi:10.1530/rep.1.00664. PMID 16049158.
Natkunam Y, Vainer G, Chen J, et al. (2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176–83. doi:10.3324/haematol.10724. PMID 17296566.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Cleynen I, Brants JR, Peeters K, et al. (2007). "HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB". Mol. Cancer Res. 5 (4): 363–72. doi:10.1158/1541-7786.MCR-06-0331. PMID 17426251.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073792 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033581 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10190901-5] Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC 2193003. PMID 10190901.

[pmid9891060-6] Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.

[entrez-7] "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

IGF2BP2

See also

References

Further reading