IER3

IER3
Identifiers
Aliases	IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDs	OMIM: 602996 MGI: 104814 HomoloGene: 2894 GeneCards: IER3
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	30,744,548 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	35,822,923 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• integral component of membrane; • membrane; • cell nucleus; • cytosol;
Biological process	• anatomical structure morphogenesis; • regulation of response to DNA damage stimulus; • negative regulation of apoptotic process; • apoptotic process; • regulation of phosphatidylinositol 3-kinase signaling; • regulation of cell death;
	Sources:Amigo / QuickGO
Orthologs
	8870
	15937
ENSG00000237155; ENSG00000137331; ENSG00000206478; ENSG00000235030; ENSG00000227231;
	ENSG00000230128
	ENSMUSG00000003541
	P46695
	P46694; Q91VZ5
	NM_052815; NM_003897
	NM_133662
	NP_003888
	NP_598423
	Wikidata
View/Edit Human	View/Edit Mouse

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.[5][6]

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[7]

References

ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 GRCh38: Ensembl release 89: ENSG00000237155, ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003541 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.
Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID 9703517.
"Entrez Gene: IER3 immediate early response 3".

Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis". Apoptosis. 8 (1): 11–8. doi:10.1023/A:1021688600370. PMID 12510147.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Schäfer H, Trauzold A, Siegel EG, et al. (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line". Cancer Res. 56 (11): 2641–8. PMID 8653710.
Pietzsch A, Büchler C, Aslanidis C, Schmitz G (1997). "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine". Biochem. Biophys. Res. Commun. 235 (1): 4–9. doi:10.1006/bbrc.1997.6715. PMID 9196025.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pietzsch A, Büchler C, Schmitz G (1998). "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene". Biochem. Biophys. Res. Commun. 245 (3): 651–7. doi:10.1006/bbrc.1998.8500. PMID 9588170.
Schäfer H, Diebel J, Arlt A, et al. (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB". FEBS Lett. 436 (2): 139–43. doi:10.1016/S0014-5793(98)01109-0. PMID 9781666.
Kobayashi T, Pittelkow MR, Warner GM, et al. (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3". Biochem. Biophys. Res. Commun. 251 (3): 868–73. doi:10.1006/bbrc.1998.9556. PMID 9791001.
Kumar R, Kobayashi T, Warner GM, et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID 9878538.
Schäfer H, Arlt A, Trauzold A, et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID 10448082.
Feldmann KA, Pittelkow MR, Roche PC, et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues". Histochem. Cell Biol. 115 (6): 489–97. doi:10.1007/s004180100284. PMID 11455449.
Zhang Y, Schlossman SF, Edwards RA, et al. (2002). "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 878–83. doi:10.1073/pnas.022326699. PMC 117399. PMID 11782530.
Im HJ, Pittelkow MR, Kumar R (2002). "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1". J. Biol. Chem. 277 (17): 14612–21. doi:10.1074/jbc.M109414200. PMC 2895739. PMID 11844788.
Ohki R, Yamamoto K, Mano H, et al. (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". J. Hypertens. 20 (4): 685–91. doi:10.1097/00004872-200204000-00026. PMID 11910304.
Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression". Oncogene. 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID 12032839.
Garcia J, Ye Y, Arranz V, et al. (2002). "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation". EMBO J. 21 (19): 5151–63. doi:10.1093/emboj/cdf488. PMC 129026. PMID 12356731.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 GRCh38: Ensembl release 89: ENSG00000237155, ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003541 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8603392-5] Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.

[pmid9703517-6] Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID 9703517.

[entrez-7] "Entrez Gene: IER3 immediate early response 3".

IER3

References

Further reading