Heavy meromyosin

Heavy meromyosin (HMM) is the larger of the two fragments obtained from the muscle protein myosin II following limited proteolysis by trypsin or chymotrypsin.[1] HMM contains two domains S-1 and S-2, S-1 contains is the globular head that can bind to actin while the S-2 domain projects at and angle from light meromyosin (LMM) connecting the two meromyosin fragments.[2]

HMM is used to determine the polarity of actin filaments by decorating them with HMM then viewing them under the electron microscope.[1]

References
  1. "Answers - The Most Trusted Place for Answering Life's Questions". Answers.com. Retrieved 2018-01-24.
  2. "Heavy meromyosin - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2018-01-24.


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