HYMAI
In molecular biology, Hydatidiform mole associated and imprinted (non-protein coding), also known as HYMAI, is a long non-coding RNA. It is an imprinted gene, which is paternally expressed.[1] Overexpression of HYMAI and the protein-coding gene PLAG1 causes transient neonatal diabetes mellitus type 1 (TNDM1).[2]
See also
- Long noncoding RNA
References
- Arima T, Drewell RA, Oshimura M, Wake N, Surani MA (2000). "A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC". Genomics. 67 (3): 248–255. doi:10.1006/geno.2000.6266. PMID 10936046.
- Mackay DJ, Temple IK (2010). "Transient neonatal diabetes mellitus type 1". Am J Med Genet C Semin Med Genet. 154C (3): 335–342. doi:10.1002/ajmg.c.30272. PMID 20803656.
Further reading
- Arima T, Yamasaki K, John RM, Kato K, Sakumi K, Nakabeppu Y, et al. (2006). "The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice". Genomics. 88 (5): 650–658. doi:10.1016/j.ygeno.2006.07.005. PMID 16928428.
- Gloyn AL, Mackay DJ, Weedon MN, McCarthy MI, Walker M, Hitman G, et al. (2006). "Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach". Diabetes. 55 (8): 2272–2276. doi:10.2337/db06-0216. PMID 16873690.
- Arima T, Wake N (2006). "Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis". Cytogenet Genome Res. 113 (1–4): 247–252. doi:10.1159/000090839. PMID 16575187.
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