HUWE1

HUWE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKK, 3G1N, 3H1D, 2MUL
Identifiers
Aliases	HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, MRXST
External IDs	OMIM: 300697 MGI: 1926884 HomoloGene: 45994 GeneCards: HUWE1
Gene location (Human)
Chr.	X chromosome (human)[1]
End	53,686,728 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	151,935,417 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding; • ubiquitin-protein transferase activity; • RNA binding; • transferase activity; • GO:1904264, GO:1904822 ubiquitin protein ligase activity;
Cellular component	• cytoplasm; • extracellular exosome; • membrane; • nucleoplasm; • extracellular region; • cytosol; • secretory granule lumen; • ficolin-1-rich granule lumen; • cell nucleus;
Biological process	• cellular response to DNA damage stimulus; • cell differentiation; • protein monoubiquitination; • histone ubiquitination; • DNA repair; • protein ubiquitination; • base-excision repair; • positive regulation of protein targeting to mitochondrion; • protein polyubiquitination; • neutrophil degranulation; • protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10075
	59026
	ENSG00000086758
	ENSMUSG00000025261
	Q7Z6Z7
	Q7TMY8
	NM_031407
	NM_021523
	NP_113584
	NP_067498
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.[5][6][7]

It performs the third step (ligation) in binding ubiquitin to proteins in a process called ubiquitination which tags the proteins for disposal.

References

GRCh38: Ensembl release 89: ENSG00000086758 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025261 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (Nov 2000). "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases". Trends Cell Biol. 10 (10): 429–39. doi:10.1016/S0962-8924(00)01834-1. PMID 10998601.
"Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1".

Gu J, Dubner R, Fornace AJ, Iadarola MJ (1995). "UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation". Oncogene. 11 (10): 2175–8. PMID 7478539.
Gu J, Ren K, Dubner R, Iadarola MJ (1994). "Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene" (PDF). Brain Res. Mol. Brain Res. 24 (1–4): 77–88. doi:10.1016/0169-328X(94)90120-1. PMID 7968380.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoon SY, Lee Y, Kim JH, et al. (2005). "Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein". Biochem. Biophys. Res. Commun. 326 (1): 7–17. doi:10.1016/j.bbrc.2004.11.004. PMID 15567145.
Liu Z, Oughtred R, Wing SS (2005). "Characterization of E3Histone, a Novel Testis Ubiquitin Protein Ligase Which Ubiquitinates Histones". Mol. Cell. Biol. 25 (7): 2819–31. doi:10.1128/MCB.25.7.2819-2831.2005. PMC 1061639. PMID 15767685.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Chen D, Kon N, Li M, et al. (2005). "ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor". Cell. 121 (7): 1071–83. doi:10.1016/j.cell.2005.03.037. PMID 15989956.
Zhong Q, Gao W, Du F, Wang X (2005). "Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis". Cell. 121 (7): 1085–95. doi:10.1016/j.cell.2005.06.009. PMID 15989957.
Warr MR, Acoca S, Liu Z, et al. (2005). "BH3-ligand regulates access of MCL-1 to its E3 ligase". FEBS Lett. 579 (25): 5603–8. doi:10.1016/j.febslet.2005.09.028. PMID 16213503.
Adhikary S, Marinoni F, Hock A, et al. (2005). "The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation". Cell. 123 (3): 409–21. doi:10.1016/j.cell.2005.08.016. PMID 16269333.

External links

HUWE1 human gene location in the UCSC Genome Browser.
HUWE1 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086758 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025261 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9205841-5] Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.

[pmid10998601-6] Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (Nov 2000). "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases". Trends Cell Biol. 10 (10): 429–39. doi:10.1016/S0962-8924(00)01834-1. PMID 10998601.

[entrez-7] "Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1".

HUWE1

References

Further reading

External links