HIST1H4C

Histone H4 is a protein that in humans is encoded by the HIST1H4C gene.[4][5][6]

H4C3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH4C3, H4/g, H4FG, dJ221C16.1, histone cluster 1, H4c, histone cluster 1 H4 family member c, H4 clustered histone 3, HIST1H4C, H4C5, H4C4, H4C9, H4C12, H4-16, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2
External IDsOMIM: 602827 MGI: 2140113 HomoloGene: 134234 GeneCards: H4C3
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,103,876 bp[1]
End26,104,310 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8364

97122

Ensembl

ENSG00000197061

n/a

UniProt

P62805

P62806

RefSeq (mRNA)

NM_003542

NM_033596

RefSeq (protein)
Location (UCSC)Chr 6: 26.1 – 26.1 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000197061 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: HIST1H4C histone cluster 1, H4c".

Further reading


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