HIST1H3I

H3C11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WKJ, 3B95, 2C1J, 3AYW, 3WA9, 3U4S, 5AVB, 2CV5, 5AV5, 3U31, 2UXN, 3AZK, 2C1N, 5C11, 3QO2, 3X1V, 5C13, 4A0J, 4U68, 5AV8, 4LLB, 3U5O, 1O9S, 4FT2, 4HON, 3W99, 3ZVY, 4Z0R, 5AVC, 1CT6, 1Q3L, 3O37, 3W97, 3SOW, 3KMT, 4YM6, 4A7J, 3UEE, 2KWK, 4F4U, 3UEF, 3UIG, 4BD3, 3AZL, 4QBR, 4F56, 3AFA, 4LKA, 5CPK, 5FFV, 3V43, 5CH1, 3U5P, 3AZI, 3U5N, 3AZH, 3UIK, 4QBQ, 1U35, 4UY4, 2OT7, 5AV9, 2B2W, 3U3D, 3AZF, 3W98, 4I51, 4X3K, 4FWF, 2B2T, 2B2V, 4A0N, 2KWJ, 3WAA, 3QJ6, 5DAH, 3AZG, 3AZE, 3X1T, 3RIY, 2L75, 3A1B, 2VPG, 4QBS, 3O35, 5CPJ, 3ZG6, 4YM5, 3AZJ, 2RI7, 3AZN, 3AVR, 5CPI, 2LBM, 3W96, 3O34, 2M0O, 4L7X, 5CH2, 5AV6, 3AZM, 4UP0, 3X1S, 2OX0, 3UII, 3SOU, 4N4H, 4TN7, 1CS9, 3X1U, 4LXL, 2B2U, 2OQ6, 3RIG, 5C3I, 4YHP, 5B24, 5D6Y, 4YHZ, 4Z2M, 5HJD, 5HJC, 5HJB, 5B2I, 5HYN, 5FB0, 5FB1, 5IQL, 5B2J, 5JIN
Identifiers
Aliases	H3C11, H3.f, H3/f, H3FF, histone cluster 1, H3i, histone cluster 1 H3 family member i, H3 clustered histone 11, HIST1H3I, H3C4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C6, H3C1
External IDs	OMIM: 602814 MGI: 2448326 HomoloGene: 134496 GeneCards: H3C11
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	27,872,315 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	23,562,369 bp[2]
Gene ontology
Molecular function	• DNA binding; • histone binding; • GO:0001948 protein binding; • protein heterodimerization activity; • cadherin binding; • nucleosomal DNA binding;
Cellular component	• nuclear nucleosome; • membrane; • nucleoplasm; • protein complex; • chromosome; • extracellular region; • nuclear chromosome; • extracellular exosome; • nuclear chromosome, telomeric region; • nucleosome; • cell nucleus; • macromolecular complex;
Biological process	• telomere organization; • cellular protein metabolic process; • positive regulation of gene expression, epigenetic; • protein heterotetramerization; • blood coagulation; • DNA replication-dependent nucleosome assembly; • regulation of gene silencing; • chromatin silencing at rDNA; • negative regulation of gene expression, epigenetic; • chromatin organization; • regulation of gene silencing by miRNA; • nucleosome assembly; • interleukin-7-mediated signaling pathway; • regulation of megakaryocyte differentiation; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	8354
	319151
	ENSG00000275379
	ENSMUSG00000069273
	P68431
	P84228
	NM_003533
	NM_178205
	NP_066298; NP_003520; NP_003525; NP_003527
NP_835587; NP_473386; NP_835734; NP_835512; NP_835510;
	NP_783584; NP_835511; NP_038576
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene.[5][6][7][8]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[8]

References

GRCh38: Ensembl release 89: ENSG00000275379 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000069273 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albig W, Meergans T, Doenecke D (January 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
Albig W, Doenecke D (December 1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
"Entrez Gene: HIST1H3I histone cluster 1, H3i".

Lusic M, Marcello A, Cereseto A, Giacca M (December 2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (October 2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (November 2000). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
El Kharroubi A, Piras G, Zensen R, Martin MA (May 1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000275379 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069273 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9031620-5] Albig W, Meergans T, Doenecke D (January 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.

[pmid9439656-6] Albig W, Doenecke D (December 1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.

[pmid12408966-7] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-8] "Entrez Gene: HIST1H3I histone cluster 1, H3i".

HIST1H3I

Function

References

Further reading