HIST1H3H

Histone H3.1 is a protein that in humans is encoded by the HIST1H3H gene.[4][5][6]

H3C10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C10, H3/k, H3F1K, H3FK, histone cluster 1, H3h, histone cluster 1 H3 family member h, HIST1H3H, H3 clustered histone 10, H3C4, H3C7, H3C12, H3C2, H3C8, H3C3, H3C6, H3C1, H3C11
External IDsOMIM: 602818 MGI: 2448319 HomoloGene: 134491 GeneCards: H3C10
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.1Start27,810,064 bp[1]
End27,811,300 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8357

319150

Ensembl

ENSG00000278828

n/a

UniProt

P68431

P84228

RefSeq (mRNA)

NM_003536

NM_178203

RefSeq (protein)

NP_066298
NP_003520
NP_003525
NP_003527

Location (UCSC)Chr 6: 27.81 – 27.81 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000278828 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: HIST1H3H histone cluster 1, H3h".

Further reading

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