HIST1H3A

Histone H3.1 is a protein that in humans is encoded by the HIST1H3A gene.[4][5][6]

H3C1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C1, H3/A, H3FA, histone cluster 1, H3a, histone cluster 1 H3 family member a, HIST1H3A, H3 clustered histone 1, H3C4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C6, H3C11
External IDsOMIM: 602810 MGI: 2448322 HomoloGene: 134332 GeneCards: H3C1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,020,490 bp[1]
End26,020,900 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8350

319149

Ensembl

ENSG00000275714

n/a

UniProt

P68431

P84228

RefSeq (mRNA)

NM_003529

NM_178204

RefSeq (protein)

NP_066298
NP_003520
NP_003525
NP_003527

Location (UCSC)Chr 6: 26.02 – 26.02 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000275714 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: HIST1H3A histone cluster 1, H3a".

Further reading

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