HIST1H2AD

H2AC7
Identifiers
Aliases	H2AC7, H2A.3, H2A/g, H2AFG, histone cluster 1, H2ad, histone cluster 1 H2A family member d, H2A clustered histone 7, HIST1H2AD
External IDs	OMIM: 602792 MGI: 2448306 HomoloGene: 137350 GeneCards: H2AC7
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	26,199,243 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	23,751,598 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • protein heterodimerization activity; • molecular function;
Cellular component	• nuclear chromatin; • nucleosome; • extracellular exosome; • cell nucleus; • chromosome;
Biological process	• chromatin silencing; • chromatin organization; • biological process;
	Sources:Amigo / QuickGO
Orthologs
	3013
	319172
	ENSG00000196866
	ENSMUSG00000061615
	P20671
C0HKE2; B2RVF0; C0HKE1; C0HKE3; C0HKE4;
	C0HKE5; C0HKE6; C0HKE7; C0HKE8; C0HKE9
	NM_021065
	NM_175660
	NP_066409
NP_001171015.1; NP_783591.2; NP_835489.1; NP_835491.1; NP_835492.1;
	NP_835493.1; NP_835494.1; NP_835495.1; NP_835496.1; NP_835493; NP_835496; NP_835489; NP_835495; NP_835494; NP_835492; NP_835491; NP_783591; NP_001171015; NP_783591; NP_835493; NP_835496; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_001171015.1; NP_783591.2; NP_835489.1; NP_835491.1; NP_835492.1; NP_835493.1; NP_835494.1; NP_835495.1; NP_835496.1; NP_835493; NP_835496; NP_835489; NP_835495; NP_835494; NP_835492; NP_835491; NP_783591; NP_001171015; NP_835489; NP_835494; NP_835495; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835494; NP_835489; NP_835495; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835495; NP_835489; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835492; NP_835491; NP_835489; NP_835495; NP_835494; NP_783591; NP_001171015; NP_835491; NP_835489; NP_835495; NP_835494; NP_835492; NP_783591; NP_001171015; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]

References

GRCh38: Ensembl release 89: ENSG00000196866 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000061615 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
"Entrez Gene: HIST1H2AD histone cluster 1, H2ad".

Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196866 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061615 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119399-5] Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.

[pmid12408966-6] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-7] "Entrez Gene: HIST1H2AD histone cluster 1, H2ad".

HIST1H2AD

References

Further reading