HIST1H1E

H1-4
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3TZD, 5JJZ
Identifiers
Aliases	H1-4, histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5, histone cluster 1 H1 family member e, RMNS, HIST1H1E, H1.4 linker histone, cluster member
External IDs	OMIM: 142220 HomoloGene: 130534 GeneCards: H1-4
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	26,157,107 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • chromatin DNA binding; • GO:0001948 protein binding; • RNA binding; • nucleotide binding; • double-stranded DNA binding; • calcium ion binding; • ATP binding; • GTP binding; • AMP binding; • dATP binding; • ADP binding; • nucleosomal DNA binding;
Cellular component	• nuclear heterochromatin; • nucleosome; • extracellular exosome; • cell nucleus; • chromosome; • nuclear nucleosome; • nuclear chromatin; • nuclear euchromatin;
Biological process	• regulation of transcription from RNA polymerase II promoter; • histone H3-K4 trimethylation; • nucleosome assembly; • nucleosome positioning; • negative regulation of transcription from RNA polymerase II promoter; • histone H3-K27 trimethylation; • regulation of transcription, DNA-templated; • chromosome condensation; • negative regulation of chromatin silencing; • negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	3008
	n/a
	ENSG00000168298
	n/a
	P10412
	n/a
	NM_005321
	n/a
	NP_005312; NP_005312.1
	n/a
	Wikidata
View/Edit Human

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.[3][4][5]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[5]

References

GRCh38: Ensembl release 89: ENSG00000168298 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
"Entrez Gene: HIST1H1E histone cluster 1, H1e".

Ohe Y, Hayashi H, Iwai K (1986). "Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b". J. Biochem. 100 (2): 359–68. doi:10.1093/oxfordjournals.jbchem.a121722. PMID 3782055.
Strom R, Santoro R, D'Erme M, et al. (1995). "Specific variants of H1 histone regulate CpG methylation in eukaryotic DNA". Gene. 157 (1–2): 253–6. doi:10.1016/0378-1119(95)91236-S. PMID 7607502.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Morrison H, Jeppesen P (2003). "Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells". Chromosome Res. 10 (7): 579–95. doi:10.1023/A:1020966719605. PMID 12498347.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Daujat S, Zeissler U, Waldmann T, et al. (2006). "HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding". J. Biol. Chem. 280 (45): 38090–5. doi:10.1074/jbc.C500229200. PMID 16127177.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Trojer P, Li G, Sims RJ, et al. (2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell. 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168298 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1916825-3] Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.

[pmid12408966-4] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-5] "Entrez Gene: HIST1H1E histone cluster 1, H1e".

HIST1H1E

References

Further reading