HEPN1

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [3]

HEPN1
Identifiers
AliasesHEPN1, hepatocellular carcinoma, down-regulated 1
External IDsOMIM: 611641 HomoloGene: 134601 GeneCards: HEPN1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q24.2Start124,919,244 bp[1]
End124,920,677 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

641654

n/a

Ensembl

ENSG00000221932

n/a

UniProt

Q6WQI6

n/a

RefSeq (mRNA)

NM_001037558

n/a

RefSeq (protein)

NP_001032647

n/a

Location (UCSC)Chr 11: 124.92 – 124.92 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.[4] Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000221932 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.
  4. Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID 12971969.
  5. Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID 15885354.

Further reading
  • Peng H, Fan J, Wu J, Lang J, Wang J, Liu H, Zhao S, Liao J (2013). "Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas". Cell. Physiol. Biochem. 31 (2–3): 379–88. doi:10.1159/000343375. PMID 23548416.
  • Kim HS, Jung G (2014). "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor". FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.