H2AFY2

MACROH2A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XD7
Identifiers
Aliases	MACROH2A2, macroH2A2, H2A histone family member Y2, H2AFY2, macroH2A.2 histone
External IDs	OMIM: 616141 MGI: 3037658 HomoloGene: 10246 GeneCards: MACROH2A2
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	70,112,282 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	61,784,147 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • protein heterodimerization activity; • GO:0000975 transcription regulatory region DNA binding; • chromatin DNA binding;
Cellular component	• ESC/E(Z) complex; • nucleoplasm; • chromosome; • nuclear chromatin; • nucleosome; • chromatin; • extracellular exosome; • Barr body; • nuclear chromosome, telomeric region; • cell nucleus;
Biological process	• nucleosome assembly; • chromatin silencing; • negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter; • positive regulation of keratinocyte differentiation; • dosage compensation; • negative regulation of transcription from RNA polymerase II promoter; • establishment of protein localization to chromatin; • brain development; • negative regulation of gene expression, epigenetic; • regulation of cell growth; • covalent chromatin modification; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	55506
	404634
	ENSG00000099284
	ENSMUSG00000020086
	Q9P0M6
	Q8CCK0
	NM_018649
	NM_207000
	NP_061119
	NP_996883
	Wikidata
View/Edit Human	View/Edit Mouse

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000099284 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020086 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.
Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.
"Entrez Gene: H2AFY2 H2A histone family, member Y2".

El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Dev. Cell. 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099284 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020086 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331621-5] Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.

[pmid11262398-6] Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.

[entrez-7] "Entrez Gene: H2AFY2 H2A histone family, member Y2".

H2AFY2

References

Further reading