Gunda Georg
Gunda I. Georg is a chemist who is currently the Professor and Head of the Department of Medicinal Chemistry,[1] Regents Professor,[2] McKnight Presidential Chair, Robert Vince Endowed Chair at University of Minnesota and the Co-Editor-in-Chief of American Chemical Society's Journal of Medicinal Chemistry.[3] Her research interests are total synthesis and semisynthesis as well as evaluating biologically active agents.[4] A cited expert in her field,[5] she was elected to the American Association for the Advancement of Science in 1996[6] and inducted in the Medicinal Chemistry Hall of Fame in 2017.[7] In 2019, she was announced as the 2020 winner and first woman to receive the Alfred Burger Award in Medicinal Chemistry (established by GlaxoSmithKline, now sponsored by Gilead[8]).[9] She along with chemists, Shameem Syeda and Gustavo Blanco, are leading researchers in male contraception.[10] Dr Georg also works with her research groups to conduct research on Alzheimer's disease, epilepsy and cancer experimental therapeutics.[11]
Dr Georg is the Principal Investigator for a National Institutes of Health Center grant[12] for the Contraceptive Discovery, Development and Behavioral Research Center funded from 2017-2021. The grant work is in five interdisciplinary groups that are working on the discovery and development of non-hormonal male contraceptive agents and the investigation of contraceptive use.[13]
Dr. Georg’s work is described in over 250 peer-reviewed publications [14] and she holds a number of patents. She has trained more than 100 PhD and post-doctoral students, most of whom have pursued careers in the pharmaceutical industry.[15]
Education
She earned her B.S. in 1975 and Ph.D. in 1980 from Philipps Universitat Marburg.[16]
Selected publications
- Hawkinson, J. E.; Sinville, R.; Mudaliar, D.; Shetty, J.; Ward, T.; Herr, J. C.; Georg, G. I. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem 2017, (accepted). DOI: 10.1002/cmdc.201700503.
- Ayoub, A.; Hawk, M. L.; Herzig, R. J.; Wisniewski, A. J.; Gee, C. Zhu, J.-Y.; Berndt, N.; Scott, T. G.; Qi, J.; Jun, Q.; Bradner, J. E.; Ward, T. R.; Schönbrunn, E.; Georg, G. I.; Pomerantz, W. C. K. BET Bromodomain Inhibitors with One-step Synthesis Discovered from a Virtual Screen. J. Med. Chem. 2017, 60, 4805-4817.
- Syeda, S. S.; Carlson, E. J.; Miller, M. R.; Francis, R.; David E. Clapham, D. E.; Lishko, P. V.; Hawkinson, J. E.; Hook, D.; Georg, G. I. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem. Biol. 2016, 11, 452-459.
- Patil, S.; Lis, L. G.; Schumacher, R. J.; Norris, B. J.; Morgan, M. L.; Cuellar, R. A. D.; Blazar, B. R.; Suryanarayanan, R.; Gurvich, V. J.; Georg, G. I. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon adenocarcinoma and Ovarian Cancer. J. Med. Chem. 2015, 58, 9334-9344.
- Syeda, S. S.; Jakkaraj, S.; Georg, G. I. Scalable synthesis of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015, 56, 3454-3457.
- Coulup, S. K.; Huang, D. S.; Wong, H. L.; Georg, G. I. Identification of the Metabolic Profile of the ?-Tubulin-binding Natural Product (-)-Pironetin. J. Med. Chem. 2019, 62, 1684-1689.
- Jakkaraj, S. R.; Young, V. G.; Georg, G. I. Syntheses of PDE3A Inhibitor ORG9935 and Determination of the Absolute Stereochemistries of its Enantiomers by X-ray Crystallography. Tetrahedron 2018, 74, 2769-2774.
- Miao, Z.; Guan, X.; Jiang, J.; Georg, G. I. BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status. In Targeting Protein-Protein Interactions by Small Molecules. Editors C. Sheng and G. I. Georg; Springer Nature Singapore; 2018, Chapter 11, pp 287-315.
- Paulson,C. N.; Guan,X.; Ayoub,A. M.; Chan, A.; Karim, R. M.; Pomerantz,W. K. C.; Schönbrunn, E.; Georg,G. I.; Hawkinson, J. E.Design, Synthesis and Characterization of a Pan-BET Fluorescent Polarization Bromodomain Probe. ACS Med. Chem. Lett. 2018, 9, 1223-12229.
References
- "Gunda I. Georg, PhD". College of Pharmacy - University of Minnesota. Retrieved 2020-03-06.
- "Three U of M Regents Professors named". umn.edu. Retrieved September 4, 2019.
- "Editor". acs.org. Retrieved November 27, 2017.
- "Gunda Georg". umn.edu. Retrieved November 27, 2017.
- "Gunda Georg". Retrieved November 27, 2017.
- "Gunda Georg". aaas.org. Archived from the original on December 1, 2017. Retrieved November 27, 2017.
- "MEDI Hall of Fame Inductees".
- "Alfred Burger Award in Medicinal Chemistry".
- Wang, Linda. "ACS 2020 national award winners". Chemical & Engineering News.
- "University of Minnesota scientists may have discovered a male birth control pill". startribune.com. Retrieved January 29, 2019.
- "Georg, Gunda". Emily Taylor Center for Women & Gender Equity. 2013-06-12. Retrieved 2020-03-06.
- "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". projectreporter.nih.gov. Retrieved 2020-03-06.
- "Georg Research Group - Research Projects". sites.google.com. Retrieved 2020-03-06.
- "NCBI MyBibliography". nih.gov. Retrieved September 4, 2019.
- "Gunda Georg". acsmedchem.org.
- "Gunda Georg". umn.edu. 2016-05-05. Retrieved November 27, 2017.