Glutaurine

Glutaurine
Names
	IUPAC name N-(2-Sulfoethyl)-L-glutamine
	Other names γ-Glutamyltaurine; γ-GT; γ-L-Glutamyltaurine[1]
Identifiers
CAS Number	56488-60-9 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2106758;
ChemSpider	62003;
KEGG	C05844;
PubChem CID	68759;
UNII	B5T2Z06Y9N ;
CompTox Dashboard (EPA)	DTXSID20205030 ;
	InChI InChI=1S/C7H14N2O6S/c8-5(7(11)12)1-2-6(10)9-3-4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14,15)/t5-/m0/s1 Key: WGXUDTHMEITUBO-YFKPBYRVSA-N; InChI=1/C7H14N2O6S/c8-5(7(11)12)1-2-6(10)9-3-4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14,15)/t5-/m0/s1 Key: WGXUDTHMEITUBO-YFKPBYRVBF;
	SMILES O=C(NCCS(=O)(=O)O)CC[C@@H](C(=O)O)N;
Properties
Chemical formula	C7H14N2O6S
Molar mass	173.1897
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Glutaurine is an endogenous dipeptide which is an amide formed from glutamic acid and taurine.

Biological role

Glutaurine is an antiepileptic with antiamnesia properties. Glutaurine was discovered in the parathyroid in 1980, and later in the mammalian brain. This led to studies on intrinsic and synthetic taurine peptides, and the suggestion that γ-glutamyltransferase (GGT; γ-glutamyl-transpeptidase) in the brain is responsible for its in vivo formation.[2]

The versatile molecule mimics the anxiolytic drug diazepam, and is implicated in phenomena from feline aggression to amphibian metamorphosis, radiation protection, and the glutamatergic system in schizophrenic disorders.[2]

References

"56488-60-9 CAS Manufactory". Chemicalbook.com. Retrieved 2012-04-21.
Bittner, S.; Win, T.; Gupta, R. (2005). "γ-L-glutamyltaurine". Amino Acids. 28 (4): 343–356. doi:10.1007/s00726-005-0196-7. PMID 15838590.

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[1] "56488-60-9 CAS Manufactory". Chemicalbook.com. Retrieved 2012-04-21.

[Bittner-2] Bittner, S.; Win, T.; Gupta, R. (2005). "γ-L-glutamyltaurine". Amino Acids. 28 (4): 343–356. doi:10.1007/s00726-005-0196-7. PMID 15838590.