GYLTL1B

LARGE2
Identifiers
Aliases	LARGE2, PP5656, GYLTL1B, glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2
External IDs	OMIM: 609709 MGI: 2443769 HomoloGene: 27362 GeneCards: LARGE2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	45,929,096 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	92,374,869 bp[2]
Gene ontology
Molecular function	• transferase activity; • catalytic activity; • manganese ion binding; • metal ion binding; • xylosyltransferase activity; • transferase activity, transferring glycosyl groups; • UDP-xylosyltransferase activity; • glucuronosyltransferase activity; • GO:0001948 protein binding;
Cellular component	• integral component of membrane; • Golgi apparatus; • membrane; • Golgi membrane;
Biological process	• protein glycosylation; • metabolism; • protein O-linked mannosylation; • muscle cell cellular homeostasis; • protein O-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	120071
	228366
	ENSG00000165905
	ENSMUSG00000040434
	Q8N3Y3
	Q5XPT3
	NM_001300721; NM_001300722; NM_152312
	NM_001166633; NM_001290773; NM_001290774; NM_001290775; NM_172670
	NP_001287650; NP_001287651; NP_689525
	NP_001160105; NP_001277702; NP_001277703; NP_001277704; NP_766258
	Wikidata
View/Edit Human	View/Edit Mouse

Glycosyltransferase-like protein LARGE2 is an enzyme that in humans is encoded by the GYLTL1B gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000165905 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040434 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F (Feb 2005). "Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy". Hum Mol Genet. 14 (5): 657–65. doi:10.1093/hmg/ddi062. PMID 15661757.
Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE (Sep 2005). "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies". Glycobiology. 15 (10): 912–23. doi:10.1093/glycob/cwi094. PMID 15958417.
"Entrez Gene: GYLTL1B glycosyltransferase-like 1B".

Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Fujimura K, Sawaki H, Sakai T, et al. (2005). "LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE". Biochem. Biophys. Res. Commun. 329 (3): 1162–71. doi:10.1016/j.bbrc.2005.02.082. PMID 15752776.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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