GSTO1

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[5][6][7]

GSTO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDsOMIM: 605482 MGI: 1342273 HomoloGene: 37971 GeneCards: GSTO1
EC number1.20.4.2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q25.1Start104,235,356 bp[1]
End104,267,459 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9446

14873

Ensembl

ENSG00000148834

ENSMUSG00000025068

UniProt

P78417
Q5TA02

O09131

RefSeq (mRNA)

NM_004832
NM_001191002
NM_001191003

NM_010362

RefSeq (protein)

NP_001177931
NP_001177932
NP_004823

NP_034492

Location (UCSC)Chr 10: 104.24 – 104.27 MbChr 19: 47.85 – 47.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000148834 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025068 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem. 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391.
  6. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.
  7. "Entrez Gene: GSTO1 glutathione S-transferase omega 1".
  8. Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the omega class of glutathione transferases". Meth. Enzymol. Methods in Enzymology. 401: 78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN 978-0-12-182806-6. PMID 16399380.

Further reading


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