GPSM2

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[5][6][7]

GPSM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2, G protein signaling modulator 2
External IDsOMIM: 609245 MGI: 1923373 HomoloGene: 56584 GeneCards: GPSM2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p13.3Start108,875,350 bp[1]
End108,934,545 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29899

76123

Ensembl

ENSG00000121957

ENSMUSG00000027883

UniProt

P81274

Q8VDU0

RefSeq (mRNA)

NM_013296
NM_001321038
NM_001321039

NM_029522

RefSeq (protein)

NP_083798

Location (UCSC)Chr 1: 108.88 – 108.93 MbChr 3: 108.68 – 108.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][7]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1[8] and GNAI2.[6][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000121957 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027883 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
  6. Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
  7. "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
  8. Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
  9. Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P81274 (Human G-protein-signaling modulator 2) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q8VDU0 (Mouse G-protein-signaling modulator 2) at the PDBe-KB.
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