GPM6B

GPM6B
Identifiers
Aliases	GPM6B, M6B, glycoprotein M6B
External IDs	OMIM: 300051 MGI: 107672 HomoloGene: 128189 GeneCards: GPM6B
Gene location (Human)
Chr.	X chromosome (human)[1]
End	13,938,638 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	166,388,988 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• molecular function;
Cellular component	• integral component of membrane; • membrane raft; • cell membrane; • membrane;
Biological process	• regulation of focal adhesion assembly; • protein transport; • multicellular organism development; • negative regulation of serotonin uptake; • cell differentiation; • negative regulation of protein localization to cell surface; • regulation of actin cytoskeleton organization; • extracellular matrix assembly; • ossification; • nervous system development; • positive regulation of bone mineralization; • neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	2824
	14758
	ENSG00000046653
	ENSMUSG00000031342
	Q13491
	P35803
	NM_001001994; NM_001001995; NM_001001996; NM_005278; NM_001318729
NM_001177955; NM_001177956; NM_001177957; NM_001177958; NM_001177959;
	NM_001177960; NM_001177961; NM_001177962; NM_023122
	NP_001001994; NP_001001995; NP_001001996; NP_001305658; NP_005269
NP_001171426; NP_001171427; NP_001171428; NP_001171429; NP_001171430;
	NP_001171431; NP_001171432; NP_001171433; NP_075611
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene.[5][6]

In melanocytic cells, GPM6B gene expression may be regulated by MITF.[7]

References

GRCh38: Ensembl release 89: ENSG00000046653 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031342 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
"Entrez Gene: GPM6B glycoprotein M6B".
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Yan Y, Lagenaur C, Narayanan V (1993). "Molecular cloning of M6: identification of a PLP/DM20 gene family". Neuron. 11 (3): 423–31. doi:10.1016/0896-6273(93)90147-J. PMID 8398137.
Narayanan V, Olinsky S, Dahle E, et al. (1998). "Mutation analysis of the M6b gene in patients with Rett syndrome". Am. J. Med. Genet. 78 (2): 165–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<165::AID-AJMG13>3.0.CO;2-L. PMID 9674909.
Yoshida M, Shan WS, Colman DR (1999). "Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system". J. Neurosci. Res. 57 (1): 13–22. doi:10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E. PMID 10397631.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Werner H, Dimou L, Klugmann M, et al. (2002). "Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes". Mol. Cell. Neurosci. 18 (6): 593–605. doi:10.1006/mcne.2001.1044. PMID 11749036.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Henneke M, Wehner LE, Hennies HC, et al. (2005). "Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome". Am. J. Med. Genet. A. 128 (2): 156–8. doi:10.1002/ajmg.a.30068. PMID 15214007.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000046653 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031342 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661015-5] Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.

[entrez-6] "Entrez Gene: GPM6B glycoprotein M6B".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

GPM6B

References

Further reading