GCM2

GCM2
Identifiers
Aliases	GCM2, GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2
External IDs	OMIM: 603716 MGI: 1861438 HomoloGene: 3490 GeneCards: GCM2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	10,882,041 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	41,111,035 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding; • metal ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus;
Biological process	• transcription, DNA-templated; • parathyroid gland development; • cellular phosphate ion homeostasis; • regulation of transcription, DNA-templated; • cellular calcium ion homeostasis; • multicellular organism development; • gliogenesis; • positive regulation of transcription from RNA polymerase II promoter; • cell differentiation involved in embryonic placenta development; • regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	9247
	107889
	ENSG00000124827
	ENSMUSG00000021362
	O75603
	O09102
	NM_004752
	NM_008104
	NP_004743
	NP_032130
	Wikidata
View/Edit Human	View/Edit Mouse

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.[5][6]

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM][6]

References

GRCh38: Ensembl release 89: ENSG00000124827 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021362 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene". FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992.
"Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)".

Kammerer M, Pirola B, Giglio S, Giangrande A (1999). "GCMB, a second human homolog of the fly glide/gcm gene". Cytogenet. Cell Genet. 84 (1–2): 43–7. doi:10.1159/000015210. PMID 10343099.
Correa P, Akerström G, Westin G (2002). "Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism". Clin. Endocrinol. 57 (4): 501–5. doi:10.1046/j.1365-2265.2002.01627.x. PMID 12354132.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Maret A, Bourdeau I, Ding C, et al. (2004). "Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin". J. Clin. Endocrinol. Metab. 89 (1): 8–12. doi:10.1210/jc.2003-030733. PMID 14715818.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kebebew E, Peng M, Wong MG, et al. (2005). "GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism". Surgery. 136 (6): 1261–6. doi:10.1016/j.surg.2004.06.056. PMID 15657585.
Thomée C, Schubert SW, Parma J, et al. (2005). "GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone". J. Clin. Endocrinol. Metab. 90 (5): 2487–92. doi:10.1210/jc.2004-2450. PMID 15728199.
Baumber L, Tufarelli C, Patel S, et al. (2006). "Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism". J. Med. Genet. 42 (5): 443–8. doi:10.1136/jmg.2004.026898. PMC 1736051. PMID 15863676.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124827 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021362 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9928992-5] Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene". FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992.

[entrez-6] "Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)".

GCM2

References

Further reading