GALNT13

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.[5][6][7]

GALNT13
Identifiers
AliasesGALNT13, GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13
External IDsOMIM: 608369 MGI: 2139447 HomoloGene: 62167 GeneCards: GALNT13
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q23.3-q24.1Start153,871,922 bp[1]
End154,453,979 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

114805

271786

Ensembl

ENSG00000144278

ENSMUSG00000060988

UniProt

Q8IUC8

Q8CF93

RefSeq (mRNA)

NM_001301627
NM_052917

NM_173030

RefSeq (protein)

NP_766618

Location (UCSC)Chr 2: 153.87 – 154.45 MbChr 2: 54.44 – 55.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000144278 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060988 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Kikuno R, Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
  6. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H (Dec 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". J Biol Chem. 278 (1): 573–84. doi:10.1074/jbc.M203094200. PMID 12407114.
  7. "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.