Ftx (gene)

In molecular biology, FTX transcript, XIST regulator (non-protein coding), also known as FTX (Five prime to Xist), is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene.[2] FTX contains several microRNAs within its introns.[3] It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter.[3]

THCYTX
Identifiers
AliasesFTXFtxThrombocytosisfamilial X-linked
External IDsGeneCards:
Orthologs
SpeciesHumanMouse
Entrez

84434

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
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See also
  • Long noncoding RNA

References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
  3. Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P, et al. (2011). "Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region". Hum Mol Genet. 20 (4): 705–718. doi:10.1093/hmg/ddq516. PMID 21118898.
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