Farnesyl-diphosphate farnesyltransferase 1

FDFT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EZF, 3ASX, 3LEE, 3Q2Z, 3Q30, 3V66, 3VJ8, 3VJ9, 3VJA, 3VJB, 3VJC, 3WC9, 3WCD, 3WCF, 3WCH, 3WCI, 3WCJ, 3WCL, 3WCM, 3WEF, 3WEG, 3WEH, 3WEI, 3WEJ, 3WEK, 3WSA
Identifiers
Aliases	FDFT1, DGPT, ERG9, SQS, SS, farnesyl-diphosphate farnesyltransferase 1, SQSD
External IDs	OMIM: 184420 MGI: 102706 HomoloGene: 3281 GeneCards: FDFT1
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	11,839,304 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	63,179,578 bp[2]
Gene ontology
Molecular function	• transferase activity; • catalytic activity; • transferase activity, transferring alkyl or aryl (other than methyl) groups; • farnesyl-diphosphate farnesyltransferase activity; • squalene synthase activity; • GO:0001948 protein binding; • metal ion binding;
Cellular component	• integral component of membrane; • membrane; • intracellular membrane-bounded organelle; • endoplasmic reticulum; • endoplasmic reticulum membrane;
Biological process	• steroid metabolic process; • sterol biosynthetic process; • lipid biosynthetic process; • lipid metabolism; • cholesterol metabolic process; • biosynthetic process; • isoprenoid biosynthetic process; • metabolism; • steroid biosynthetic process; • cholesterol biosynthetic process; • ergosterol biosynthetic process; • farnesyl diphosphate metabolic process; • regulation of lipid metabolic process; • regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2222
	14137
	ENSG00000079459; ENSG00000284967
	ENSMUSG00000021273
	P37268; Q6IAX1
	P53798
NM_001287742; NM_001287743; NM_001287744; NM_001287745; NM_001287747;
	NM_001287748; NM_001287749; NM_001287750; NM_001287751; NM_001287756; NM_004462
	NM_010191; NM_001360211
NP_001274671; NP_001274672; NP_001274673; NP_001274674; NP_001274676;
	NP_001274677; NP_001274678; NP_001274679; NP_001274680; NP_001274685; NP_004453; NP_001274671.1; NP_001274672.1; NP_004453.3
	NP_034321; NP_001347140
	Wikidata
View/Edit Human	View/Edit Mouse

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. [5]

Function

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

References

ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Retrieved 2016-06-25.

Farnesyl-diphosphate farnesyltransferase 1

Function

References

Further reading