FUCA2

FUCA2
Identifiers
Aliases	FUCA2, dJ20N2.5, fucosidase, alpha-L- 2, plasma, alpha-L-fucosidase 2
External IDs	OMIM: 136820 MGI: 1914098 HomoloGene: 119 GeneCards: FUCA2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	143,511,720 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	13,519,035 bp[2]
Gene ontology
Molecular function	• hydrolase activity; • alpha-L-fucosidase activity; • hydrolase activity, acting on glycosyl bonds; • GO:0001948 protein binding;
Cellular component	• extracellular exosome; • extracellular region; • extracellular; • azurophil granule lumen; • endoplasmic reticulum lumen; • lysosome;
Biological process	• fucose metabolic process; • metabolism; • glycoside catabolic process; • neutrophil degranulation; • post-translational modification; • cellular protein metabolic process; • carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2519
	66848
	ENSG00000001036
	ENSMUSG00000019810
	Q9BTY2; Q7Z6V2
	Q99KR8
	NM_032020
	NM_025799; NM_001330198
	NP_114409
	NP_001317127; NP_080075
	Wikidata
View/Edit Human	View/Edit Mouse

Plasma alpha-L-fucosidase (see alpha-L-fucosidase) is an enzyme that in humans is encoded by the FUCA2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000001036 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019810 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Eiberg H, Mohr J, Nielsen LS (Oct 1984). "Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system". Clin Genet. 26 (1): 23–9. doi:10.1111/j.1399-0004.1984.tb00782.x. PMID 6590153.
"Entrez Gene: FUCA2 fucosidase, alpha-L- 2, plasma".

Narahara K, Tsuji K, Yokoyama Y, et al. (1991). "Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2". Am. J. Med. Genet. 40 (3): 348–53. doi:10.1002/ajmg.1320400322. PMID 1951444.
O'Brien JS, Willems PJ, Fukushima H, et al. (1988). "Molecular biology of the alpha-L-fucosidase gene and fucosidosis". Enzyme. 38 (1–4): 45–53. doi:10.1159/000469189. PMID 2894306.
Cordero OJ, Merino A, Páez de la Cadena M, et al. (2001). "Cell surface human alpha-L-fucosidase". Eur. J. Biochem. 268 (11): 3321–31. doi:10.1046/j.1432-1327.2001.02237.x. PMID 11389735.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000001036 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019810 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6590153-5] Eiberg H, Mohr J, Nielsen LS (Oct 1984). "Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system". Clin Genet. 26 (1): 23–9. doi:10.1111/j.1399-0004.1984.tb00782.x. PMID 6590153.

[entrez-6] "Entrez Gene: FUCA2 fucosidase, alpha-L- 2, plasma".

FUCA2

References

Further reading