FLRT2

FLRT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V2C, 4V2D
Identifiers
Aliases	FLRT2, fibronectin leucine rich transmembrane protein 2
External IDs	OMIM: 604807 MGI: 3603594 HomoloGene: 8291 GeneCards: FLRT2
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	85,654,428 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	95,785,215 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein binding, bridging; • signal transducer activity, downstream of receptor; • fibroblast growth factor receptor binding; • protein kinase inhibitor activity; • chemorepellent activity;
Cellular component	• cytoplasm; • organelle membrane; • integral component of membrane; • endoplasmic reticulum membrane; • membrane; • intracellular membrane-bounded organelle; • intercellular junction; • focal adhesion; • proteinaceous extracellular matrix; • synapse; • integral component of plasma membrane; • extracellular region; • cell junction; • endoplasmic reticulum; • neuron projection; • extracellular exosome; • cell membrane; • extracellular; • extracellular matrix;
Biological process	• negative chemotaxis; • negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • cell adhesion involved in heart morphogenesis; • heart morphogenesis; • axon guidance; • multicellular organism development; • cell adhesion; • basement membrane organization; • regulation of neuron migration; • negative regulation of JAK-STAT cascade; • positive regulation of synapse assembly; • fibroblast growth factor receptor signaling pathway; • biological process;
	Sources:Amigo / QuickGO
Orthologs
	23768
	399558
	ENSG00000185070
	ENSMUSG00000047414
	O43155
	Q8BLU0
	NM_001346143; NM_001346144; NM_001346145; NM_001346146; NM_013231
	NM_201518
	NP_001333072; NP_001333073; NP_001333074; NP_001333075; NP_037363
	NP_958926
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.[5][6][7]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.[7]

References

GRCh38: Ensembl release 89: ENSG00000185070 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047414 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (December 1999). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (September 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Developmental Biology. 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596.
"Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185070 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047414 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10644439-5] Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (December 1999). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.

[pmid16872596-6] Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (September 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Developmental Biology. 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596.

[entrez-7] "Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

FLRT2

Function

References

Further reading