FCMR
Fc fragment of IgM receptor is a protein that in humans is encoded by the FCMR gene. [5]
| FCMR | |||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||
| Aliases | FCMR, TOSO, FAIM3, Fc fragment of IgM receptor | ||||||||||||||||||||||||
| External IDs | OMIM: 606015 MGI: 1916419 HomoloGene: 48347 GeneCards: FCMR | ||||||||||||||||||||||||
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| Orthologs | |||||||||||||||||||||||||
| Species | Human | Mouse | |||||||||||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||||||||||
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| Location (UCSC) | Chr 1: 206.9 – 206.92 Mb | Chr 1: 130.87 – 130.88 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||
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Function
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).
References
- GRCh38: Ensembl release 89: ENSG00000162894 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000042474 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Fc fragment of IgM receptor". Retrieved 2016-03-24.
Further reading
- Sigruener A, Buechler C, Bared SM, Grandl M, Aslanidis C, Ugocsai P, Gehrmann M, Schmitz G (2007). "E-LDL upregulates TOSO expression and enhances the survival of human macrophages". Biochem. Biophys. Res. Commun. 359 (3): 723–8. doi:10.1016/j.bbrc.2007.05.169. PMID 17553462.
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