Erminio Costa

Erminio "Mimo" Costa (March 9, 1924 – November 28, 2009) was an Italian-American neuroscientist.[3] His research interests covered brain serotonergic activity in health and disease, benzodiazepine-GABA interactions,[4] benzodiazepine action at GABAA receptors, neurophysiological role of neurosteroids,[5] and GABAergic dysfunction and changes in the expression of reelin and GAD67 in schizophrenia.[6] He published more than 1,000 articles.[7] The June 2011 issue of the journal Neuropharmacology was dedicated to him.[8]

Erminio Costa
BornMarch 9, 1924
Cagliari, Sardinia, Kingdom of Italy
DiedNovember 28, 2009(2009-11-28) (aged 85)[1]
Chevy Chase, Maryland, U.S.
NationalityItalian
CitizenshipAmerican
Alma materUniversity of Cagliari
Known forResearch on serotonin, the GABA receptor, and metabotropic glutamate receptors
Spouse(s)Ingeborg Hanbauer
ChildrenMichael, Max and Robert (Robert died in 2006)[2]
Scientific career
FieldsNeuropharmacology
InstitutionsColumbia University, Georgetown University

Career
  • July 1947 - M.D. 110/110 cum laude, University of Cagliari, Italy
  • 1950-1960 - Thudichum Psychiatric Research Laboratory, Galesburg Research Hospital, Galesburg, Illinois
  • 1960-1965 - Deputy Chief, Laboratory of Chemical Pharmacology at NHLI - NIH, Bethesda, Maryland
  • 1965-1968 - Associate Professor of Pharmacology and Neurology, College of Physicians and Surgeons of Columbia University, New York, NY
  • 1968-1985 - Chief of the Laboratory of Preclinical Pharmacology, NIMH, St. Elizabeths Hospital, Washington, DC
  • 1985-1994 - Director and Founder, Institute of Neuroscience, and Professor of Pharmacology, Georgetown University, Washington, DC
  • 1994-1995 - Director, Center for Neuropharmacology, Nathan Kline Institute for Psychiatric Research, New York University, New York, NY
  • 1995 - Scientific Director, Psychiatric Institute, Professor of Biochemistry in Psychiatry, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois
  • 1982 - Member, National Academy of Sciences
  • 1991 - Member of "Accademia dei Lincei" founded by Galileo Galilei in 1602, Rome

Books
  • Advances in Biochemical Psychopharmacology (1969)
  • Biochemistry and Pharmacology of the Basal Ganglia (1966)
  • Biochemistry of Simple Neuronal Models (1970)
  • Neurosteroids and Brain Function (1991)
  • The Endorphins - Vol. 18 (1985)

See also
  • Bernard Brodie, in whose laboratory Costa worked for a time.

References
  1. Social Security Death Index, 1935-2014. Social Security Administration.
  2. Grayson, D. R.; Guidotti, A. (2010). "Erminio Costa". Neuropsychopharmacology. 35 (13): 2646. doi:10.1038/npp.2009.231. PMC 3055564.
  3. Clayton, Paula J.; Fatemi, S. Hossein (2008). The medical basis of psychiatry. Totowa, NJ: Humana Press. ISBN 1-58829-917-1.
  4. Barondes, Samuel H. (2003). Better than Prozac: Creating the next generation of psychiatric drugs. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-515130-5.
  5. Pinna, G.; Uzunova, V.; Matsumoto, K.; Puia, G.; Mienville, J. M.; Costa, E.; Guidotti, A. (2000-01-28). "Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol". Neuropharmacology. 39 (3): 440–448. doi:10.1016/s0028-3908(99)00149-5. ISSN 0028-3908. PMID 10698010.
  6. Costa E, Chen Y, Davis J, Dong E, Noh JS, Tremolizzo L, Veldic M, Grayson DR, Guidotti A (February 2002). "REELIN and schizophrenia: a disease at the interface of the genome and the epigenome". Mol. Interv. 2 (1): 47–57. doi:10.1124/mi.2.1.47. PMID 14993361. Archived from the original on 2013-04-14.
  7. "UIC, Dept. of Psychiatry News: Erminio Costa, M.D., Logs 1,000th Publication". Archived from the original on 30 April 2004.
  8. Bloom FE (June 2011). "Mentored and inspired by Mimo: a tribute to Erminio Costa". Neuropharmacology. 60 (7–8): 1003–6. doi:10.1016/j.neuropharm.2010.09.019. PMID 20869374.
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